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Fig. 1 | European Journal of Medical Research

Fig. 1

From: Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

Fig. 1

Schematic structure of lipopolysaccharide (LPS) and the TLR4 receptor complex. a LPS is composed of lipid A (endotoxin), core oligosaccharide and O-antigen. b Components of the TLR4–MD2–CD14 receptor complex. Different TLR4 regions are shown: leucine-rich repeats (LRR), a hypervariable region (HYP) and the intracellular TIR domain. myeloid differentiation factor 88 (MyD88), MyD88 adapter-like protein/Toll receptor IL-1 receptor domain containing adapter protein (MAL/TIRAP). LRR, leucine-rich repeats; DD, death domain; TIR, Toll receptor IL-1 receptor domain

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European Journal of Medical Research

ISSN: 2047-783X

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