Fig. 4
From: Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
The best bound conformation site of luteolin binding to AR proteins and AR protein mutation sites. A The three-dimensional structure diagram of the combination of luteolin and AR protein. B Molecular structure plan of luteolin-binding site with AR protein. C Schematic diagram of the AR protein mutation site. (AR-WT AR wild-type strain, AR-MU AR mutant strain, NR-DBD-AR DNA-binding domain of AR comprises two C4-type zinc fingers, NR-LBD-AR ligand-binding domain of the nuclear receptor androgen receptor, ligand-activated transcription regulator)