Table 3 Predicted bioactivity values of the top ten multi-target active compounds
From: Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
Molecule name | STAT3 | STAT1 | AKT1 | MYC | AR | SUM | Number of targets |
|---|---|---|---|---|---|---|---|
Quercetin | 4.042564 | 4.376751 | 6.823909 | 3.779892 | 6 | 25.02312 | 6 |
Luteolin | 4.649752 | 4.376751 | 6.823909 | 3.779892 | 5 | 24.6303 | 5 |
Kaempferol | 4.885389 | 4.376751 | 4.263763 | 3.779892 | 4.849485 | 22.15528 | 4 |
Licochalcone A | 4.522879 | 4.376751 | 8 | 3.779892 | 5 | 25.67952 | 3 |
Naringenin | 4.042564 | 4.376751 | 9.420216 | 3.779892 | 4.849485 | 26.46891 | 2 |
7-Acetoxy-2-methylisoflavone | 4.30103 | 3.395774 | 5 | 5.592397 | 6 | 24.2892 | 2 |
Glabridin | 4.042564 | 4.376751 | 6.451893 | 3.779892 | 5 | 23.6511 | 2 |
Phaseolinisoflavan | 4.042564 | 4.730487 | 5 | 3.779892 | 5.173394 | 22.72634 | 2 |
Licoisoflavanone | 4.042564 | 4.376751 | 5 | 3.779892 | 4.849485 | 22.04869 | 2 |
7-Methoxy-2-methyl isoflavone | 4.042564 | 4.730487 | 4.263763 | 3.779892 | 4.849485 | 21.66619 | 2 |