Fig. 2

Survival analysis of the HLMRG signature in the discovery set (n = 479). A Distribution of risk scores derived from the HLMRG signature, and expression profile of the five genes that comprised the HLMRG signature in the discovery set. B Distribution of 28-day survival status in the high-risk (n = 239) and low-risk (n = 240) groups. Sepsis patients were classified into different risk groups using the median risk score as the cutoff. C Kaplan–Meier estimate of the 28-day survival according to the HLMRG signature. The difference between the two curves was determined by the two-side log-rank test. D ROC analysis of the sensitivity and specificity of 28-day survival prediction by the HLMRG signature risk score, Mars endotype, and combination of the two factors. P-values were obtained from the pairwise comparisons of the AUCs using the Delong method. **P < 0.01, ***P < 0.001, ns no significance