Fig. 3

Survival analysis of the HLMRG signature in the validation set (n = 371). A Distribution of risk scores derived from the HLMRG signature, and expression profile of the five genes that comprised the HLMRG signature in the validation set. B Distribution of 28-day survival status in the high-risk (n = 163) and low-risk (n = 208) groups. Sepsis patients were classified into different risk groups based on the same cutoff used in the discovery set. C ROC analysis of the sensitivity and specificity of 28-day survival prediction by the HLMRG signature risk score, SRS group, and combination of the two factors. P-values were obtained from the pairwise comparisons of the AUCs using the Delong method. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significance