Fig. 4

Association between the HLMRG signature and clinical features of sepsis patients. A Heatmap showing correlation of the HLMRG signature with age, gender, source of infection, thrombocytopenia, diabetes mellitus and Mars endotype in the discovery set (n = 479). NA, not available. B Heatmap showing correlation of the HLMRG signature with age, gender and SRS group in the validation set (n = 371). Comparisons of the risk score in sepsis patients with disperse source of infection (C), Mars endotype (D), and SRS group (E). The Wilcoxon rank-sum test was used to compare risk scores between two groups, while the Kruskal–Wallis test was applied for comparisons among more than two groups. ***P < 0.001, ns no significance