Table 1 circRNAs and osteosarcoma chemotherapy resistance

circ-CHI3L1.2

Increases resistance to cisplatin through the miR-340-5p/LPAAT axis

[27]

hsa_circ_0004674

Regulates the miR-342-3p and FBN1 axis to promote OS doxorubicin resistance

[33]

CircPVT1

Via the miR-24-3p and KLF8, encourages OS cell proliferation and chemoresistance

[28]

TRIAP1 is regulated by miR-137, which in turn contributes to OS cells' doxorubicin resistance

[37]

Regulates ABCB1 and plays a role in OS cells' resistance to doxorubicin and cisplatin

[29]

circUBAP2

Boosts SEMA6D expression. The Wnt/-catenin signaling pathway can be activated to increase cisplatin resistance

[30]

hsa_circ_0000073

OS cells are more resistant to methotrexate because of it by upregulating NRAS and sponging miR-145-5p and miR-151-3p

[40]

circ_0081001

when knockdown, methotrexate sensitivity is increased by controlling the miR-494-3p and TGM2 axis

[41]

CircDOCK1

Via the miR-339-3p and IGF1R axis, aids in osteogenic sarcoma tumorigenesis and resistance to cisplatin

[31]

CircITCH

Through the miR-524/RASSF6 axis, downregulation of circITCH encourages OS development and resistance to doxorubicin

[38]

Circular RNA LARP4

Sponging microRNA-424 increases OS chemosensitivity to cisplatin and doxorubicin

[32]

Circular RNA_ANKIB1

Via microRNA-26b-5p, it speeds up resistance to chemotherapies

[39]