Table 1 Baseline data of septic shock patients between 28 days survival and no-survival groups
Total n = 1251 | 28-day survival group n = 897 | 28-day non-survival group n = 354 | P-value | |
|---|---|---|---|---|
Age, median (IQR) | 68.0 (55.0–78.0) | 67.0 (55.0–77.0) | 71.0 (59.3–80.0) | < 0.001 |
Gender, Male, n (%) | 845 (67.5) | 597 (66.6) | 248 (70.2) | 0.233 |
APACHE II score, median (IQR) | 19.0 (14.0–25.0) | 18.0 (13.0–23.0) | 24.0 (19.0–30.0) | < 0.001 |
SOFA score, median (IQR) | 8.0 (5.0–10.0) | 7.0 (5.0–10.0) | 10.0 (7.0–12.5) | < 0.001 |
Comorbidities, n (%) | ||||
Hypertension | 657 (52.5) | 466 (52.0) | 191 (54.0) | 0.523 |
Diabetes mellitus | 336 (26.9) | 223 (24.9) | 113 (31.9) | 0.011 |
Chronic congestive heart failure | 237 (18.9) | 158 (17.6) | 79 (22.3) | 0.059 |
Coronary heart disease | 206 (16.5) | 135 (15.1) | 71 (20.1) | 0.032 |
Chronic renal failure | 93 (7.4) | 62 (6.9) | 31 (8.8) | 0.262 |
COPD | 86 (6.9) | 48 (5.4) | 38 (10.7) | 0.001 |
Cirrhosis | 25 (2.0) | 16 (1.8) | 9 (2.5) | 0.388 |
Cancer (solid tumor) | 237 (18.9) | 157 (17.5) | 80 (22.4) | 0.038 |
Source of infection, n (%) | ||||
Lung | 634 (50.7) | 415 (46.3) | 219 (61.9) | < 0.001 |
Abdomen | 415 (33.2) | 320 (35.7) | 95 (26.8) | 0.002 |
Blood | 47 (3.8) | 31 (3.5) | 16 (4.5) | 0.373 |
Skin | 34 (2.7) | 27 (3.0) | 7 (2.0) | 0.312 |
Urinary tract | 89 (7.1) | 80 (9.1) | 9 (2.5) | < 0.001 |
Others | 30 (2.4) | 22 (2.5) | 8 (2.3) | 0.841 |
Hemodynamic variables, median (IQR) | ||||
mSBP24h (mmHg) | 123.0 (116.6–131.1) | 123.2 (116.9–131.0) | 122.2 (114.8–129.5) | 0.174 |
mDBP24h (mmHg) | 63.3 (57.6–69.3) | 63.6 (58.3–69.2) | 62.0 (55.7–68.9) | 0.003 |
mMAP24h (mmHg) | 83.1 (78.1–88.4) | 83.3 (78.6–88.2) | 81.6 (76.7–88.0) | 0.011 |
mHR24h (beats per minute) | 94.6 (83.0–105.8) | 93.0 (82.1–103.3) | 100.7 (87.3–112.2) | < 0.001 |
mCVP24h (mmHg) | 8.2 (6.6–10.2) | 8.1 (6.5–9.9) | 8.6 (6.9–10.7) | 0.009 |
Vasoactive drugs, median | ||||
Dopamine, n (%) | 139 (11.1) | 97 (10.8) | 42 (11.9) | 0.594 |
Dobutamine, n (%) | 135 (10.8) | 93 (10.4) | 43 (12.1) | 0.363 |
Norepinephrine, n (%) | 979 (78.3) | 689 (76.8) | 290 (81.9) | 0.048 |
Epinephrine, n (%) | 91 (7.3) | 68 (7.6) | 23 (6.5) | 0.506 |
Vasopressin, n (%) | 31 (2.5) | 24 (2.7) | 7 (2.0) | 0.474 |
VIS | 35.5 (17.6–70.6) | 35.7 (17.3–66.7) | 33.9 (18.2–76.9) | 0.445 |
Mechanical ventilation, n (%) | 894 (71.5) | 604 (67.3) | 290 (81.9) | < 0.001 |
New CRRT, n (%) | 312 (24.9) | 165 (18.4) | 147 (41.5) | < 0.001 |