Fig. 1

Hexarelin Attenuated Renal Function in I/R-induced AKI. A I/R-induced AKI model was established in SD rats; B serum creatine, BUN levels and relative expression of KIM-1 of different groups (C) H&E staining and (D) PAS staining of (I) control, (II) sham, (III) AKI, (IV) Hexarelin pretreatment before AKI and (V) Saline pretreatment before AKI groups; (VI) tubular injury score of different in vivo groups. Light microscopic images showing renal tubular epithelial cells shedding, tubular dilatation [yellow (III and V)], renal tubular epithelial cell necrosis, intratubular cast and basement membrane exposed [blue (III and V)], enlargement of bowman space [grey (III and V)], renal interstitial edema [red (III and V)], renal interstitial inflammatory cell infiltration [green (III and V)], severe degeneration and vacuolar of tubular epithelial cells [black (III and V)] in AKI and saline pretreatment before AKI groups. All data are shown as mean ± SD. *P < 0.05, **P < 0.01 versus control; ^#P < 0.05, ^##P < 0.01 versus AKI