Fig. 5
From: Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway
Hexarelin protected apoptosis against I/R-induced AKI associated with MDM2 and p53. A GSEA analysis of GEO dataset of GSE98622 samples; B Volcano plot DEGs of IR-AKI samples and (C) Heatmap of genes of apoptosis signaling pathway; D 5 core transcription factors were obtained using MCC algorithm after transcription factors enrichment prediction analysis; E Molecular docking was performed to confirm the combination of Hexarelin and MDM2; F Detailed combination information of Hexarelin and MDM2, the two formed hydrogen bonds at the position of GLU-25 and THR-26 from MDM2 on a sizeable hydrophobic pocket in the N-terminal domain of MDM2