Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease

Table 2 Mean changes from baseline in key outcome measures at 3 and 12 months in two groups of patients

	Control group		Intervention group		F_{time × between groups}/P value	F_{main effect between groups}/P value	F_{time main effect}/P value
	3 months after treatment	12 months after treatment	3 months after treatment	12 months after treatment	F_{time × between groups}/P value	F_{main effect between groups}/P value	F_{time main effect}/P value
FEV1	0.10 ± 0.04	0.11 ± 0.11	0.17 ± 0.06	0.24 ± 0.15	21.713/< 0.001	–	–
FEV₁(%, predicted)	3.29 ± 1.72	3.77 ± 4.98	6.58 ± 3.02	9.19 ± 6.58	31.216/< 0.001	–	–
FVC	0.22 ± 0.40	0.22 ± 0.42	0.2 5 ± 0.19	0.34 ± 0.27	1.705/0.193	0.259/0.613	29.280/< 0.001
mMRC	− 0.41 ± 0.57	− 0.52 ± 0.63	− 0.68 ± 0.55	− 1.00 ± 0.67	3.947/0.025	–	–
6MWT	24.83 ± 8.78	31.52 ± 25.49	42.79 ± 17.53	78.07 ± 36.20	16.988/< 0.001	–	–
CAT	− 2.76 ± 1.50	3.52 ± 1.94	− 4.93 ± 2.51	− 7.36 ± 3.64	16.741/< 0.001	–	–

F_{time × between groups:} interaction effect of group and time; F_{between groups:} main effect between groups; F_{time: time} main effect. Data were expressed as mean ± standard deviation for changes from baseline to 3 and 12 months, with significance level at P value < 0.05
FEV₁ forced expiratory volume in the first–second, FVC forced vital capacity, mMRC modified Medical Research Council, 6MWT 6-min walk test, CAT COPD assessment test

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