Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study

Table 1 MR estimates from different methods of assessing the causal effect of low grip strength on osteoarthritis

Exposures	Outcomes	No. of IVs	Heterogeneity test	MR-egger	MR results	OR (95% CI)	p
Exposures	Outcomes	No. of IVs	Cochran’s q (p)	Intercept (p)	Method	OR (95% CI)	p
GS	KOA	8	65.242 (< 0.001)	0.009 (0.784)	IVW	1.205 (0.837, 1.734)	0.316
					MR-egger	1.093 (0.840,1.421)	0.529
					WM	1.088 (0.883,1.340)	0.431
					PRESSO (3)	1.122 (0.927, 1.358)	0.304
GS	HOA	7	5.395 (0.494)	0.012 (0.540)	IVW	1.090 (0.924,1.609)	0.307
					MR-egger	0.862 (0.419,1.771)	0.703
					WM	1.079 (0.924,1.287)	0.501
					PRESSO (0)	1.090 (0.924,1.609)	0.307
GS	TKR	6	23.799 (< 0.001)	0.016 (0.767)	IVW	1.659 (0.983,2.803)	0.058
					MR-egger	1.601 (0.929,2.755)	0.774
					WM	1.582 (1.102,2.272)	0.013
					PRESSO (0)	1.659 (0.983,2.803)	0.058
GS	THR	7	10.208 (< 0.001)	0.003 (0.909)	IVW	1.035 (0.792,1.353)	0.798
					MR-egger	1.181 (0.771,1.808)	0.003
					WM	1.148 (0.849,1.553)	0.369
					PRESSO (0)	1.035 (0.792,1.353)	0.798

MR Mendelian randomization, IVs instrumental variables, GS grip strength, KOA knee osteoarthritis, HOA, hip osteoarthritis, TKR total knee replacement, THR total hip replacement, ALM appendicular lean mass, OR odds ratio, CI confidence interval, IVW inverse variance weighted, WM weighted median, PRESSO Pleiotropy RESidual Sum and Outlier

ISSN: 2047-783X