Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study

Table 2 MR estimates from different methods of assessing the causal effect of appendicular lean mass on osteoarthritis

Exposures	Outcomes	No. of IVs	Heterogeneity test	MR-egger	MR results	OR (95% CI)	p
Exposures	Outcomes	No. of IVs	Cochran’s q (p)	Intercept (p)	Method	OR (95% CI)	p
ALM	KOA	486	993.209 (< 0.001)	0.003 (0.079)	IVW	1.104 (1.041,1.171)	0.001
					MR-egger	0.967 (0.825,1.134)	0.679
					WM	1.0.85 (1.009,1.166)	0.037
					PRESSO (9)	1.134 (1.073, 1.199)	< 0.001
ALM	HOA	487	890.952 (< 0.001)	0.004 (0.052)	IVW	1.151 (1.071,1.237)	< 0.001
					MR-egger	0.961 (0.791,1.168)	0.690
					WM	1.154 (1.056,1.261)	0.002
					PRESSO (7)	1.155 (1.081,1.235)	< 0.001
ALM	TKR	487	917.707 (< 0.001)	0.005 (0.034)	IVW	1.114 (1.007,1.232)	0.036
					MR-egger	0.845 (0.643,1.112)	0.321
					WM	1.114 (1.007,1.232)	0.098
					PRESSO (11)	1.190 (1.084,1.307)	< 0.001
ALM	THR	486	894.639 (< 0.001)	0.006 (0.014)	IVW	1.203 (1.099,1.316)	< 0.001
					MR-egger	0.906 (0.711,1.156)	0.429
					WM	1.143 (1.020,1.281)	0.021
					PRESSO (8)	1.226 (1.129,1.332)	< 0.001

MR Mendelian randomization, IVs instrumental variables, GS grip strength, KOA knee osteoarthritis, HOA hip osteoarthritis, TKR total knee replacement, THR total hip replacement, ALM appendicular lean mass, OR odds ratio, CI confidence interval, IVW inverse variance weighted, WM weighted median, PRESSO Pleiotropy RESidual Sum and Outlier

ISSN: 2047-783X