Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study

Table 4 MR estimates from different methods of assessing the causal effect of total knee and hip replacement on sarcopenia

Exposures	Outcomes	No. of IVs	Heterogeneity test	MR-egger	MR results	Beta/OR (95% CI)	p
Exposures	Outcomes	No. of IVs	Cochran’s q (p)	Intercept (p)	Method	Beta/OR (95% CI)	p
TKR	GS	5	56.813(< 0.001)	0.047(0.758)	IVW	0.999(0.739,1.351)	0.997
					MR-egger	1.017(0.851,1.215)	0.864
					WM	1.138(0.968, 1.340)	0.019
					PRESSO (0)	0.999(0.739,1.351)	0.997
TKR	ALM	5	27.341(< 0.001)	0.005(0.836)	IVW	0.018	0.501
					MR-egger	0.043	0.886
					WM	0.005	0.733
					PRESSO (0)	0.018	0.501
THR	GS	22	59.120(< 0.001)	− 0.004(0.749)	IVW	1.037(0.978,1.101)	0.222
					MR-egger	1.074(0.864,1.336)	0.528
					WM	1.012(0.961,1.083)	0.519
					PRESSO (0)	1.037(0.978,1.101)	0.222
THR	ALM	17	83.332 (< 0.001)	0.007(0.157)	IVW	− 0.023	0.081
					MR-egger	− 0.087	0.072
					WM	− 0.023	0.235
					PRESSO (4)	− 0.012	0.158

MR Mendelian randomization, IVs instrumental variables, GS grip strength, KOA knee osteoarthritis, HOA hip osteoarthritis, TKR total knee replacement, THR total hip replacement, ALM appendicular lean mass, OR odds ratio, CI confidence interval, IVW inverse variance weighted, WM weighted median, PRESSO Pleiotropy RESidual Sum and Outlier

ISSN: 2047-783X