Bidirectional association between infectious gastroenteritis and inflammatory bowel disease: a population-based study

Table 3 Crude and adjusted odds ratio for the risk of IBD associated with IGE occurred in the five time-windows

Time-windows prior to the index date	All IBD cases vs. controls			CD cases vs. controls		UC cases vs. controls
Time-windows prior to the index date	Crude OR (95% CI)	aOR (95% CI)^a	p-value	aOR (95% CI)^a	p-value	aOR (95% CI)^a	p-value
≤ 1 year
Without IGE	Ref.	Ref.		Ref.		Ref.
With IGE	7.49 (6.70–8.38)	7.51 (6.66–8.46)	< 0.001	8.93 (7.18–11.11)	< 0.001	6.95 (6.02–8.01)	< 0.001
> 6 months–1 year
Without IGE	Ref.	Ref.		Ref.		Ref.
With IGE	3.07 (2.57–3.68)	2.95 (2.54–3.56)	< 0.001	3.67 (2.64–5.10)	< 0.001	2.63 (2.08–3.31)	< 0.001
> 1–3 years
Without IGE	Ref.	Ref.		Ref.		Ref.
With IGE	2.27 (2.02–2.55)	2.24 (1.98–2.54)	< 0.001	3.24 (2.63–3.99)	< 0.001	1.86 (1.59–2.17)	< 0.001
> 3–5 years
Without IGE	Ref.	Ref.		Ref.		Ref.
With IGE	1.43 (1.23–1.65)	1.40 (1.20–1.63)	< 0.001	1.67 (1.29–2.16)	< 0.001	1.28 (1.06–1.55)	0.011
> 6 months–5years
Without IGE	Ref.	Ref.		Ref.		Ref.
With IGE	1.91 (1.72–2.12)	1.89 (1.69–2.11)	< 0.001	2.63 (2.19–3.17)	< 0.001	1.59 (1.39–1.82)	< 0.001

Bold values represent p < .05
IBD inflammatory bowel disease; CD Crohn’s disease; UC ulcerative colitis; IGE infectious gastroenteritis; OR, odds ratio; aOR adjusted OR; Ref. reference group
^aadjusted for monthly insured salary, median annual family-income level, urbanization level, Charlson’s comorbidity index, any history of selected immune-realted diseases, history of chronic pulmonary disease, rheumatic disease, peptic ulcer disease, mild liver disease, diabetes without chronic complications, and diabetes with chronic complications

ISSN: 2047-783X