MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis

Taghehchian, Negin; Lotfi, Malihe; Zangouei, Amir Sadra; Akhlaghipour, Iman; Moghbeli, Meysam

doi:10.1186/s40001-023-01329-7

Table 1 Role of miRNAs in regulation of gynecological and breast cancers via FOX targeting

From: MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis

Study	Tumor type	Gene	Target	Samples	Function
Lin [52]	Breast	miR-96	FOXO3a	23 tumor samples 23 normal samples MCF-7, ZR-75-30, BT549, Bcap37, MDA-MB435, SKBR3, MDA-MB453 and T47D cell lines	Oncogene
Shen [55]	Breast	miR-204	FOXA1	MCF-7 cell line	Tumor suppressor
Salem [56]	Ovarian	miR-590-3p	FOXA2	58 tumor samples 13 plasma samples ES-2, SKOV3.ip1,OVCAR3, and HEY cell lines	Oncogene
Xu [63]	Endometrial	miR-495	FOXC1	10 tumor samples 5 normal samples AN3CA and KLE cell lines	Tumor suppressor
Zhang [72]	Cervical	miR-30a-5p	FOXD1	50 tumor samples 50 normal samples HeLa, HT-3, C33A and SiHa cell lines	Tumor suppressor
Yang [75]	Cervical	miR‑128‑3p	FOXD3	60 tumor samples 60 normal samples C33A, HeLa, HT-3 and SiHa cell lines	Tumor suppressor
Zhang [76]	Breast	miR-182	FOXF2	55 tumor samples 55 normal samples MCF-7 and MDA-MB-231 cell lines	Oncogene
Wang [77]	Ovarian	miR-182-5p	FOXF2	47 tumor samples 47 normal samples SKOV3, HO8910, A2780, OVCAR, and HOSEpiC cell lines	Oncogene
Zeng [86]	Cervical	miR-200b	FoxG1	30 tumor samples 30 normal samples HeLa and C33A cell lines	Oncogene
Gao [88]	Breast	miR-365-3p	FOXK1	93 tumor samples 93 normal samples MCF-7 and MDA-MB-231 cell lines	Oncogene
Zhang [101]	Breast	miR-26b	FOXM1	MDA-MB-231, MDA-MB-436, MDA-MB-468, MDA-MB-157, MDA-MB-435 and BT549 cell lines	Oncogene
Bayraktar [105]	Breast	miR-34a	FOXM1	MDA-MB-231, MDA-MB-436, MDA-MB-468, BT-483, SUM-149, and HCC1937 cell lines	Tumor suppressor
Yuan [107]	Breast	miR-802	FOXM1	20 tumor samples 20 normal samples MCF-7, MDA-MB-453, MDA-MB-468 and ZR-75–1 cell lines	Tumor suppressor
Li [108]	Cervical	miR-342-3p	FOXM1	27 tumor samples 27 normal samples HeLa, Caski, and C33A cell lines	Tumor suppressor
Liang [109]	Cervical	miR-4429	FOXM1	102 tumor samples 102 normal samples CaSki, ME-180, C33A, and SiHa cell lines	Tumor suppressor
Li [110]	Ovarian	miR-149-5p	FOXM1	SKOV3 and A2780 cell lines	Tumor suppressor
Hong [111]	Cervical	miR-320a	FOXM1	48 tumor samples 48 normal samples SiHa, HeLa, CaSki, C-33A, and MS751cell lines	Tumor suppressor
Gao [112]	Cervical	miR-361-5p	FOXM1	66 tumor samples 66 normal samples SiHa, HeLa, C33a, Me180 and Ms751 cell lines	Tumor suppressor
Dong [113]	Breast	miR-876-5p	FOXM1	MCF-7, BT-549, MDA-MB-231, and SKBR3 cell lines	Tumor suppressor
Tan [114]	Breast	miR-671-5p	FOXM1	30 tumor samples 30 normal samples MDA-MB-231, Hs578T, SKBR3, BT-20, MDA-MB-468, MCF-7, and T47D cell lines	Tumor suppressor
He [115]	Cervical	miR-216b	FOXM1	150 tumor samples 150 normal samples HCC94, HeLa (Cat, SiHa, Ca Ski, and C33A cell lines	Tumor suppressor
Hu [116]	Cervical	miR‑197	FOXM1	46 tumor samples 46 normal samples HeLa, C33A, CaSki and SiHa cell lines	Tumor suppressor
Shi [117]	Cervical	miR‑320	FOXM1	36 tumor samples 36 normal samples HeLa, CaSki, C33A and SiHa cell lines	Tumor suppressor
Xia [118]	Cervical	miR-374b	FOXM1	48 tumor samples 48 normal samples SiHa, Hela and CaSki cell lines	Tumor suppressor
Dai [119]	Cervical	miR-203a-5p	FOXN2	47 tumor samples 47 normal samples SiHa, C-4-I, Ca-Ski and C-33-A cell lines	Oncogene
Xu [123]	Cervical	miR-181a	FOXO1	C33A, HeLa229, MS751, HCC94, HeLa, HT-3, SiHa, CaSKi, and ME-180 cell lines	Oncogene
Xu [124]	Cervical	miR-135b	FOXO1	C33A, HCC94, HeLa, HT-3, SiHa and CaSKi cell lines	Oncogene
Yang [125]	Cervical	miR-96	FOXO1	83 tumor samples 11 normal samples C41, C33A, HeLa, CaSki, MS751, SiHa and HT-3 cell lines	Oncogene
Hou [51]	Cervical	miR-196a	FOXO1	102 tumor samples 10 normal samples MS751, C33A, HeLa, HeLa229, SiHa, HCC94, CaSKi, HT-3 and ME-180 cell lines	Oncogene
Li [128]	Breast	miR-29c	FOXO1	79 tumor samples 16 normal samples 20 healthy serum 79 BC serum MCF-7, MDA-MB-231, and MDA-MB-436 cell lines	Tumor suppressor
Liu [129]	Breast	miR-9	FOXO1	83 tumor samples 83 normal samples BT-549, MDA-MB-231, MCF7, BT-474, MDA-MB-453, MDA-MB-468 and MDA-MB-436 cell lines	Oncogene
Jin [132]	Breast	miR-10b	FOXO3a	48 tumor samples 48 normal samples MCF-7, MDA-MB-231, SK-BR-3, T47D and BT474 cell lines	Tumor suppressor
Xia [136]	Ovarian	miR-506-3p	FOXO3a	60 tumor samples 20 normal samples HO-8910PM, A2780, HO-8910, CAOV3, SKOV3, OVCA433, PEO1 and COC1cell lines	Tumor suppressor
Sang [137]	Breast	miR-182-5p	FOXO3a	230 tumor samples 44 normal samples MCF7 and T47D cell lines	Tumor suppressor
Zhu [138]	Ovarian	miR-148a	FOXO3	20 tumor samples 20 normal samples OVCAR3 and SKOV3 cell lines	Tumor suppressor
Li [139]	Cervical	miR-150	FOXO4	118 tumor samples 23 normal samples C-33A cell line	Oncogene
Hu [145]	Ovarian	miR-29c-3p	FOXP1	SKOV3 and A2780 cell lines	Tumor suppressor
Li [146]	Ovarian	miR-374b-5p	FOXP1	84 tumor samples 84 normal samples OVCAR3, 3AO, A2780 and SKOV3 cell lines	Tumor suppressor
Cheng [147]	Cervical	miR-449b-5p	FOXP1	84 tumor samples 84 normal samples HeLa, SiHa, ME180, CaSki, and C33A cell lines	Tumor suppressor
Qin [148]	Breast	miR-214-3p	FOXP2	10 tumor samples 10 normal samples MDA-MB-231, HCC1559, BT549, UACC-812, and MDA-MB-453 cell lines	Oncogene
Zhang [149]	Cervical	miR-185-3p	FOXP3	39 tumor samples 39 normal samples SiHa, HeLa, CaSki, HCC94 and C33A cell lines	Oncogene
Zhang [150]	Ovarian	miR-150-5p/3p	FOXP3	SKOV3, ES2, and A2780 cell lines	Tumor suppressor
Liu [158]	Breast	miR-146	FOXP3	20 tumor samples 20 normal samples MCF7, T47D, BT474, MDA-MB-468, and MDA-MB23 cell lines	Tumor suppressor
Wang [160]	Breast	miR-4316	FOXP4	41 tumor samples 21 normal samples BT474, MCF-7, MDA-MB-231, T47D and MDA-MB-453 cell lines	Tumor suppressor
Yang [161]	Breast	miR-296-5p	FOXP4	70 tumor samples 70 normal samples T47D, MCF-7, MDA-MB-231 and BT549 cell lines	Tumor suppressor
Han [166]	Breast	miR-937	FOXQ1	47 tumor samples 47 normal samples MDA-MB-231, MCF-7, BT-474 and SKBR3 cell lines	Tumor suppressor
Deng [167]	Endometrial	miR-202	FOXR2	90 tumor samples 40 normal samples KLE and AN3CA cell lines	Tumor suppressor
Zhang [168]	Ovarian	miR-1252	FOXR2	36 tumor samples 36 normal samples SKOV3 and HeyA-8 cell lines	Tumor suppressor

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ISSN: 2047-783X

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