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Table 2 Diagnostic value of using BALF or EBUS-GS with acid-fast staining, MGIT 960 culture, pathological examination, and Xpert for solitary pulmonary tuberculoma

From: EBUS-GS with the GeneXpert MTB/RIF assay for diagnosis of Mycobacterium tuberculosis infection of isolated pulmonary nodules

Clinical specimen

Sensitivity% (95%CI)

Specificity% (95%CI)

PPV% (95%CI)

NPV% (95%CI)

PLR (95%CI)

NLR (95%CI)

YI (95%CI)

BALF + acid-fast staining

8.69 (4/46)

100 (30/30)

100 (4/4)

41.67 (30/72)

–

0.91

0.09

0.55–16.84

100–100

100–100

30.28–53.05

0.84–0.99

0.00–0.17

BALF + MGIT 960

32.61 (15/46)

100 (30/30)

100 (15/15)

49.18 (30/61)

–

0.67

0.33

19.06–46.16

100–100

100–100

36.63–61.73

0.55–0.82

0.19–0.46

BALF + Xpert

34.78 (16/46)

100 (30/30)

100 (16/16)

50.00 (30/60)

–

0.65

0.35

21.02–48.55

100–100

100–100

37.35–62.65

0.53–0.81

0.21–0.49

BALF + Xpert + MGIT 960

36.96 (17/46)

100 (30/30)

100 (17/17)

50.85 (30/59)

–

0.63

0.37

 

23.01–50.91

100–100

100–100

38.09–63.60

 

0.51–0.79

0.23–0.51

EBUS-GS + acid-fast staining

17.19 (11/64)

100 (71/71)

100 (11/11)

57.26 (71/124)

–

0.83

0.17

7.94–26.43

100–100

100–100

48.55–65.97

0.74–0.93

0.08–0.26

EBUS-GS + MGIT 960

35.94 (23/64)

100 (71/71)

100 (23/23)

63.39 (71/112)

–

0.64

0.36

24.18–47.69

100–100

100–100

54.47–72.31

0.53–0.77

0.24–0.48

EBUS-GS + pathological examination

46.88 (30/64)

95.77 (68/71)

90.91 (30/33)

66.67 (68/102)

11.09

3.56–34.61

0.55

0.43

34.65–59.10

91.10–100

81.10–100

57.52–75.82

0.44–0.70

0.30–0.56

EBUS-GS + Xpert

57.81 (37/64)

100 (71/71)

100 (37/37)

72.45 (71/98)

–

0.42

0.58

45.71–69.91

100–100

100–100

63.60–81.29

0.32–0.56

0.46–0.70

EBUS-GS + Xpert + MGIT 960

62.50 (40/64)

100 (71/71)

100 (40/40)

74.74 (71/95)

–

0.38

0.63

50.64–74.36

100–100

100–100

66.00–83.47

0.27–0.51

0.51–0.74

EBUS-GS + Xpert + pathological examination

62.50 (40/64)

95.77 (68/71)

93.02 (40/43)

73.91 (68/92)

14.79

4.81–45.50

0.39

0.58

50.64–74.36

91.10–100

85.41–100

64.94–82.89

0.28–0.54

0.46–0.71

  1. BALF bronchoalveolar lavage fluid; MGIT Mycobacteria Growth Indicator Tube; EBUS-GS endobronchial ultrasound with guide-sheath; PPV positive predictive value; NPV negative predictive value; PLR positive likelihood ratio; NLR negative likelihood ratio; YI Youden index; CI confidence interval