Fig. 1
From: The critical role of platelet in cancer progression and metastasis
Activation of platelet by tumor further promotes the metastases of tumor in remote. Tumor cells activate platelets through various mechanisms, including secretion of the alarm protein HMGB1, release of soluble platelet agonists, induced increased expression of Hsp47, and expression of the G protein-coupled receptor CD97. Activated platelets induce EMT of tumor cells in indirect or direct ways by secreting microparticles (MPs), expressing various adhesion molecules and secreted growth factors, which further promotes the metastases of tumor in remote