Fig. 4

Establishment of GPCR–TME classifier. A Multivariate Cox regression analysis with a bootstrap algorithm screening of five types of prognostic immune cells for establishing the TME score. B Kaplan–Meier survival curves of TCGA–SKCM cohort in patients with melanoma high-TME vs. low-TME score. C Kaplan–Meier survival curves of TCGA–SKCM cohort in melanoma among the four GPCR–TME subgroups. D ROC curves reveal one-, three-, and five-AUC value of GPCR–TME classifier. GPCR G protein-coupled receptor; TME Tumor microenvironment; ROC Receiver operating characteristic curves; AUC Area under the curve; TCGA The Cancer Genome Atlas; SKCM Skin cutaneous melanoma