Table 4 The 44 differentially expressed autophagy-related genes identified in AAA samples compared with healthy samples
From: Identification and experimental validation of autophagy-related genes in abdominal aortic aneurysm
Gene symbol | Gene full name | Log FC | P-value | Sign | |
|---|---|---|---|---|---|
IL6 | Interleukin 6 | 1.854287696 | 0.000536548 | Up | |
ACSL1 | Acyl-CoA synthetase long-chain family member 1 | − 1.498992684 | 7.11E−05 | Down | |
FOXO1 | Forkhead box O1 | − 1.478291998 | 7.11E−07 | Down | |
OPTN | Optineurin | − 1.475476971 | 0.000189003 | Down | |
SYNPO2 | Synaptopodin 2 | − 1.470449509 | 0.000632708 | Down | |
UCP2 | Uncoupling protein 2 | 1.459662163 | 0.000450946 | Up | |
MAP1LC3B | Microtubule-associated protein 1 light chain 3 beta | − 1.406036738 | 5.81E−06 | Down | |
NQO1 | NAD(P)H dehydrogenase, quinone 1 | − 1.403057967 | 1.53E−05 | Down | |
HSPB8 | Heat shock protein family B (small) member 8 | − 1.32606301 | 0.000744209 | Down | |
S1PR3 | Sphingosine-1-phosphate receptor 3 | − 1.322071348 | 0.000759019 | Down | |
DNM1L | Dynamin 1 like | − 1.319501904 | 0.000156247 | Down | |
TUFM | Tu translation elongation factor, mitochondrial | − 1.316836492 | 6.54E−08 | Down | |
PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1 | − 1.294565375 | 0.000163092 | Down | |
SMAD4 | SMAD family member 4 | − 1.229514634 | 0.005736397 | Down | |
FOXO3 | Forkhead box O3 | − 1.226609084 | 7.17E−05 | Down | |
ERBB2 | Erb-b2 receptor tyrosine kinase 2 | − 1.219461333 | 2.78E−05 | Down | |
ZC3H12A | Zinc finger CCCH-type containing 12A | 1.217032418 | 0.000602389 | Up | |
OCRL | OCRL inositol polyphosphate-5-phosphatase | − 1.204585369 | 0.00010173 | Down | |
PRNP | Prion protein | − 1.189461334 | 8.64E−05 | Down | |
HMGB1 | High mobility group box 1 | − 1.182508628 | 0.000513381 | Down | |
CX3CL1 | C-X3-C motif chemokine ligand 1 | − 1.170147022 | 0.001883242 | Down | |
EEF2K | Eukaryotic elongation factor 2 kinase | − 1.153423438 | 0.000144531 | Down | |
CYB5A | Cytochrome b5 type A | − 1.15130727 | 0.000587073 | Down | |
C19ORF12 | Chromosome 19 open reading frame 12 | − 1.150038744 | 1.70E−05 | Down | |
PTPN22 | Protein tyrosine phosphatase non-receptor type 22 | 1.139013995 | 7.56E−05 | Up | |
SOD1 | Superoxide dismutase 1 | − 1.13450957 | 0.000333745 | Down | |
KEAP1 | Kelch-like ECH-associated protein 1 | − 1.132006804 | 0.000127777 | Down | |
ICMT | Isoprenylcysteine carboxyl methyltransferase | − 1.126722892 | 2.31E−06 | Down | |
PRKDC | Protein kinase, DNA-activated, catalytic subunit | − 1.120876405 | 3.47E−05 | Down | |
ARSB | Arylsulfatase B | − 1.116386777 | 0.000937924 | Down | |
DDIT4 | DNA damage-inducible transcript 4 | − 1.106453053 | 0.001543176 | Down | |
VPS36 | Vacuolar protein sorting 36 homolog | − 1.090350128 | 0.003625821 | Down | |
ATG4A | Autophagy-related 4A cysteine peptidase | − 1.05943196 | 6.17E−05 | Down | |
RAB11A | RAB11A, member RAS oncogene family | − 1.048852339 | 0.00039715 | Down | |
MAP2K1 | Mitogen-activated protein kinase kinase 1 | − 1.039636349 | 0.001667882 | Down | |
CAPN2 | Calpain 2 | − 1.038225758 | 7.10E−06 | Down | |
EI24 | EI24 autophagy-associated transmembrane protein | − 1.03818983 | 0.001317094 | Down | |
CXCL12 | C-X-C motif chemokine ligand 12 | − 1.034376299 | 0.007241633 | Down | |
SAR1A | Secretion-associated Ras-related GTPase 1A | − 1.034002436 | 0.001859123 | Down | |
TBC1D4 | TBC1 domain family member 4 | 1.026985567 | 0.001213376 | Up | |
PPARG | Peroxisome proliferator-activated receptor gamma | − 1.02321369 | 0.002583403 | Down | |
ST13 | ST13 Hsp70 interacting protein | − 1.020903612 | 0.001595684 | Down | |
MTDH | Metadherin | − 1.008135363 | 0.002910239 | Down | |
PRKCQ | Protein kinase C theta | 1.004575424 | 0.004953416 | Up | |