Table 2 single factor and multi factor analysis
Factors | Define | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95%CI) | Z (P) | HR (95%CI) | Z (P) | ||
Age |  | 1.014 (1.011–1.016) | 11.255 (< 0.001) | 1.016 (1.013–1.019) | 10.966 (0) |
Marriage | Married | Ref. | Â | Â | Â |
Single | 1.354 (1.254–1.462) | 7.723 (< 0.001) | 1.233 (1.133–1.341) | 4.854 (0) | |
Widowed | 1.576 (1.443–1.721) | 10.146 (< 0.001) | 1.317 (1.188–1.461) | 5.236 (0) | |
Other | 1.275 (1.167–1.392) | 5.384 (< 0.001) | 1.174 (1.064–1.297) | 3.178 (0.002) | |
Race | White | Ref. | Â | Â | Â |
Black | 1.341 (1.220–1.474) | 6.084 (< 0.001) | 1.205 (1.086–1.336) | 3.532 (0) | |
Other | 1.026 (0.931–1.130) | 0.512 ( > 0.05) | 1.114 (1.009–1.23) | 2.145 (0.032) | |
Sex | Female | Ref. | Â | Â | Â |
Male | 1.105 (1.041–1.173) | 3.300 (< 0.001) | 1.161 (1.085–1.241) | 4.355 (0) | |
Deposits | Yes | Ref. | Â | Â | Â |
No | 0.371 (0.335–0.410) |  − 19.456 (< 0.001) | 0.585 (0.526–0.651) | − 9.814 (0) | |
Others | 1.062 (0.958–1.178) | 1.150 ( > 0.05) | 0.802 (0.706–0.912) | − 3.359 (0.001) | |
Behav | Behav1 | Ref. | Â | Â | Â |
Behav2 | 0.508 (0.445–0.580) |  − 9.973 (P < 0.001) | 0.856 (0.745–0.984) | − 2.191 (0.028) | |
Behav3 | 0.495 (0.437–0.561) |  − 11.061 (P < 0.001) | 0.91 (0.796–1.039) | − 1.392 (0.16) | |
Other | 1.223 (1.119–1.336) | 4.459 (P < 0.001) | 1.059 (0.952–1.177) | 1.052(0.29) | |
Grade | I | Ref. | Â | Â | Â |
II | 1.420 (1.257–1.604) | 5.630 (P < 0.001) | 1.214 (1.069–1.379) | 2.991 (0.003) | |
III, IV | 2.615 (2.288–2.990) | 14.070 (P < 0.001) | 1.641 (1.419–1.898) | 6.682 (0) | |
AJCC Stage | I | Ref. | Â | Â | Â |
II | 2.123 (1.914–2.354) | 14.258 (P < 0.001) | 1.69 (1.437–1.988) | 6.332 (0) | |
III | 2.840 (2.583–3.122) | 21.607 (P < 0.001) | 1.735 (1.479–2.035) | 6.766 (0) | |
IV | 11.515 (10.421–12.723) | 47.997 (P < 0.001) | 3.658 (2.968–4.507) | 12.169 (0) | |
T | T1 | Ref. | Â | Â | Â |
T2 | 0.926 (0.817–1.050) |  − 1.110 (P > 0.05) | 0.931 (0.814–1.066) | − 1.037 (0.3) | |
T3 | 2.046 (1.864–2.246) | 15.069 (P < 0.001) | 1.138 (0.994–1.303) | 1.867 (0.062) | |
T4 | 4.487 (4.019–5.011) | 26.678 (P < 0.001) | 1.764 (1.512–2.059) | 7.201 (0) | |
N | N0/N1 | Ref. | Â | Â | Â |
N2 | 2.336 ( 2.173–2.510) | 23.080 (P < 0.001) | 1.261 (1.153–1.379) | 5.073 (0) | |
Surgery | 1 | Ref. | Â | Â | Â |
2 | 0.263 (0.246–0.281) |  − 38.849 (P < 0.001) | 0.47 (0.405–0.546) | − 9.918 (0) | |
LNSur | No | Ref. | Â | Â | Â |
Yes | 0.584 (0.550–0.621) |  − 17.110 (P < 0.001) | 1.074 (0.884–1.304) | 0.72 (0.47) | |
Unknown | 0.770 (0.588–1.010) |  − 1.884 (P > 0.05) | 1.055 (0.766–1.453) | 0.326 (0.74) | |
Radiation | Yes | Ref. | Â | Â | Â |
|  | No | 1.001 (0.944–1.062) | 0.050 (P > 0.05) | - |  |
Chemotherapy | Yes | Ref. | Â | Â | Â |
No | 0.727 (0.682–0.776) |  − 9.649 (P < 0.001) | 1.392 (1.273–1.521) | 7.265 (0) | |
CEA | Yes | Ref. | Â | Â | Â |
No | 0.422 (0.392–0.454) |  − 23.330 (P < 0.001) | 0.724 (0.668–0.784) | − 7.934 (0) | |
Others | 0.538 (0.503– 0.576) |  − 18.013 (P < 0.001) | 0.858 (0.794–0.927) | − 3.881 (0) | |
Brain | No | Ref. | Â | Â | Â |
Yes | 8.645 (5.075–14.726) | 7.937 (P < 0.001) | 2.613 (1.727–3.955) | 4.545 (0) | |
Positive | No | Ref. | Â | Â | Â |
Yes | 2.748 (2.560–2.950) | 28.004 (P < 0.001) | 1.685 (1.53–1.856) | 10.603 (0) | |
Other | 2.622 (2.437–2.820) | 25.901 (P < 0.001) | 1.239 (1.025–1.496) | 2.221 (0.026) | |
Liver | No | Ref. | Â | Â | Â |
Yes | 5.424 (5.044–5.833) | 45.580 (P < 0.001) | 1.405 (1.215–1.624) | 4.593 (0) | |
Lung | No | Ref. | Â | Â | Â |
Yes | 5.795 (5.253–6.392) | 35.117 (P < 0.001) | 1.294 (1.121–1.494) | 3.511 (0) | |
Bone | No | Ref. | Â | Â | Â |
Yes | 9.253 (7.282–11.757) | 19.049 (P < 0.001) | 1.712 (1.314–2.232) | 3.977 (0) | |
Size | < 3 cm | Ref. |  |  |  |
3–5 cm | 1.680 (1.546–1.826) | 12.242 (P < 0.001) | 1.089 (0.993–1.196) | 1.803 (0.071) | |
5–cm | 2.579 (2.387–2.786) | 24.014 (P < 0.001) | 1.256 (1.145–1.378) | 4.845 (0) | |
Malignant | 1 | Ref. | Â | Â | Â |
2 | 1.057 (0.983–1.136) | 1.498 (P > 0.05) | 1.053 (0.97–1.142) | 1.226 (0.22) | |
3– | 1.211 (1.078–1.359) | 3.233 (P < 0.05) | 1.225 (1.076–1.395) | 3.074 (0.002) | |