Fig. 2

SNHG6 mediated regulation of autophagy. Autophagy can be initiated by the activation of the UKL1 complex. The regulatory RNAs, i.e., miR-26a-5p and miR186 act as an antagonist and inhibit the activations of the UKL1 complex thus shutting down the autophagy. SNHG6 inhibits these regulatory miRNAs and makes UKL1 available to a cell which leads to the ATF3 and UKL1 complex activation and autophagosome formation that helps in cell survival. Activating transcription factor 3 (ATF3); autophagy-related protein 13 (ATG13); autophagy-related protein 101 (ATG101); microRNA-186 (miR-186); small nucleolar RNA host gene 6 (SNHG6); unc-51-like kinase 1 (ULK1); focal adhesion kinase family interacting protein of 200 kDa (FIP200)