Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity

Table 2 Multivariate logistic regression model for the differences in clinical presentation between the delta and omicron cohort

Parameter	Adjusted odds ratio (OR)^a	95% Confidence interval	P value
Clinical Severity^b of omicron variant (reference—clinical severity of delta variant)	0.13	0.04–0.30	< 0.001

^aOdd ratio adjusted for gender, age, vaccination status, profession with high risk of exposure, and any history of previous natural SARS-CoV-2 infection, respectively
^bSeverity was defined as a composite outcome variable considering need for hospitalisation, oxygen therapy, mechanical ventilation and intensive care unit (ICU) admission along with the respective days associated with each parameter

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