Fig. 1
From: The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
Mechanism of the m6A modification. The m6A-RNA methylation is modulated by writers, erasers and readers, writers mainly contain METTL3–METTL14 complex, WTAP, KAAI429, RBM15, ZCH13 and METTL4/5/16, which promote m6A methylation; erasers include FTO, ALKBH5 and ALKBH, and induce m6A demethylation; readers consist of YTHDF1-3, YTHDC1-2, IGF2BP1-3 and HNRNPs (HNRNPC, HNRNPG and HNRNPA2B1), which are involved in RNA splicing, export, decay, translation and stability