Fig. 2
From: The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer
Role of the m6A modification in thyroid cancer. Oncogenic m6A regulators (red), METTL3 and IGF2BP2, are highly expressed in thyroid cancer, and promote cell proliferation and metastasis; while tumor-suppressive m6A regulators (green), including METTL3, FTO and ALKBH5, are downregulated in thyroid cancer, which inhibit tumor progression by suppressing proliferation, metastasis and glycolysis, as well as promoting ferroptosis. APOE, apolipoprotein E; STEAP2, six transmembrane epithelial antigen of the prostate 2; STK4, serine/threonine stress kinase 4; TANs, tumor-associated neutrophils; TCF1, T-cell factor 1; TIAM1, T-lymphoma invasion and metastasis. ↑indicates upregulation, ↓ indicates downregulation, → indicates a promoting effect and ⊥ indicates an inhibitory effect