The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer

Table 1 Roles of m⁶A regulators in thyroid cancer

Regulators	Expressions	Targets	Roles	Functions	Mechanisms	References
METTL3	Up	miR-222-3p	Oncogene	Promotes tumor growth and metastasis	Promotes the expression of miR-222-3p and thus downregulates STK4	[48]
METTL3	Up	TCF1	Oncogene	Promotes proliferation and migration	Upregulates the IGF2BP2-mediated m⁶A modification of TCF1mRNA	[51]
METTL3	Down	c-Rel, RelA	Suppressor	Inhibits tumor growth	Inactivates the NF-κB pathway by cooperating with YTHDF2 and further reduces the accumulation of tumor-associated neutrophils	[52]
METTL3	Down	STEAP2	Suppressor	Inhibits PTC proliferation, EMT, migration and metastasis	Enhances the stability of STEAP2 mRNA in an m⁶A-dependent manner and inhibits the Hedgehog signaling pathway	[53]
FTO	Down	TP53	Suppressor	Inhibits tumor progression	Targets m6A methylation of TP53	[60]
FTO	Down	APOE	Suppressor	Inhibits PTC glycolysis and growth	Suppresses the expression of APOE through IGF2BP2-mediated m⁶A modification	[62]
FTO	Down	SLC7A11	Suppressor	Promotes tumor ferroptosis	Downregulates the expression of SLC7A11	[61]
ALKBH5	Down	TIAM1	Suppressor	Inhibits proliferation and promotes ferroptosis	Suppresses the expression of TIAM1 by m⁶A modification	[69]
IGF2BP2	Up	lncRNA HAGLR	Oncogene	Promotes proliferation, migration and invasion	Promotes the expression of lncRNA HAGLR in an m⁶A-dependent manner	[75]

ISSN: 2047-783X