Skip to main content

Table 2 Comparison of cytokine levels among CTD-ILD, CTD-non-ILD and HCs

From: Clinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study

Variables

HCs (n = 30), pg/mL

CTD-non-ILD (n = 30), pg/mL

CTD-ILD (n = 61), pg/mL

p value (CTD-ILD vs. CTD-non-ILD)

IL-2

0.4 (0.3–0.8)

0.9 (0.4–1.6)*

1.0 (0.6–1.7)###

0.371

IL-4

0.5 (0.1–0.9)

1.4 (1.0–2.5)***

1.5 (0.9–2.8)###

0.645

IL-5

0.1 (0–0.5)

0.7 (0.3–1.0)***

0.8 (0.3–1.3)###

0.285

IL-6

2.2 (1.3–3.7)

6.7 (2.4–32.9)***

17.8 (5.4–62.5)###

0.042

IL-8

12.5 (8.3–20.9)

44.6 (6.7–226.2)*

203.2 (25.8–663.5)###

0.031

IL-10

1.2 (0.8–1.5)

4.1 (2.9–6.0)***

4.7 (3.1–6.6)###

0.510

IL-1β

0.3 (0–1.0)

4.3 (1.6–11.8)***

6.6 (2.3–12.6)###

0.329

IL-17A

2.1 (1.1–3.7)

11.9 (4.3–19.0)***

9.5 (5.3–16.6)###

0.543

IL-12p70

1.5 (0.7–2.1)

2.4 (1.3–3.1)**

2.8 (1.8–4.7)###

0.113

TNF-α

0.9 (0.4–1.9)

2.3 (0.9–6.8)**

5.0 (2.2–17.7)###

0.026

IFN-α

0.4 (0–1.0)

2.4 (1.5–7.0)***

2.4 (1.6–4.4)###

0.923

IFN-γ

0.8 (0.5–1.2)

2.1 (1.5–3.9)***

2.4 (1.6–4.6)###

0.445

  1. CTD-ILD, connective tissue disease-associated interstitial lung disease; HCs, healthy controls
  2. *P < 0.05 (HCs vs. CTD-non-ILD), **P < 0.01 (HCs vs. CTD-non-ILD), ***P < 0.001 (HCs vs. CTD-non-ILD), ###P < 0.001 (HCs vs. CTD-ILD)