Variables | HCs (n = 30), pg/mL | CTD-non-ILD (n = 30), pg/mL | CTD-ILD (n = 61), pg/mL | p value (CTD-ILD vs. CTD-non-ILD) |
---|---|---|---|---|
IL-2 | 0.4 (0.3–0.8) | 0.9 (0.4–1.6)* | 1.0 (0.6–1.7)### | 0.371 |
IL-4 | 0.5 (0.1–0.9) | 1.4 (1.0–2.5)*** | 1.5 (0.9–2.8)### | 0.645 |
IL-5 | 0.1 (0–0.5) | 0.7 (0.3–1.0)*** | 0.8 (0.3–1.3)### | 0.285 |
IL-6 | 2.2 (1.3–3.7) | 6.7 (2.4–32.9)*** | 17.8 (5.4–62.5)### | 0.042 |
IL-8 | 12.5 (8.3–20.9) | 44.6 (6.7–226.2)* | 203.2 (25.8–663.5)### | 0.031 |
IL-10 | 1.2 (0.8–1.5) | 4.1 (2.9–6.0)*** | 4.7 (3.1–6.6)### | 0.510 |
IL-1β | 0.3 (0–1.0) | 4.3 (1.6–11.8)*** | 6.6 (2.3–12.6)### | 0.329 |
IL-17A | 2.1 (1.1–3.7) | 11.9 (4.3–19.0)*** | 9.5 (5.3–16.6)### | 0.543 |
IL-12p70 | 1.5 (0.7–2.1) | 2.4 (1.3–3.1)** | 2.8 (1.8–4.7)### | 0.113 |
TNF-α | 0.9 (0.4–1.9) | 2.3 (0.9–6.8)** | 5.0 (2.2–17.7)### | 0.026 |
IFN-α | 0.4 (0–1.0) | 2.4 (1.5–7.0)*** | 2.4 (1.6–4.4)### | 0.923 |
IFN-γ | 0.8 (0.5–1.2) | 2.1 (1.5–3.9)*** | 2.4 (1.6–4.6)### | 0.445 |