Clinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study

Table 4 Spearman correlations between clinical variables and cytokine levels in CTD-ILD patients

	LDH	ESR	CRP	PaO2/FiO2 ratio	FVC %	DLCO %	sPAH	Total GGO score	Total fibrosis score
IL-6	0.193	0.315*	0.235	− 0.463***	− 0.362*	− 0.164	0.07	0.439***	− 0.05
IL-8	0.064	0.04	− 0.02	− 0.115	− 0.036	0.213	0.062	0.239	0.013
TNF-α	− 0.018	0.136	0.199	− 0.154	− 0.309	− 0.041	− 0.069	0.085	0.017

LDH, lactate dehydrogenase; PaO2/FiO2: partial arterial oxygen pressure/inspired oxygen fraction; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; sPAH, systolic pulmonary artery pressure; GGO, ground-glass opacity

ISSN: 2047-783X