Skip to main content

Table 5 Variables associated with AE occurrence in CTD-ILD patients according to logistic regression analysis

From: Clinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study

Variables

Univariate analysis

Multivariate analysis

OR

95% CI

P value

OR

95% CI

P value

Age, years

1.011

0.967–1.057

0.640

   

Male

1.350

0.440–4.146

0.600

   

Smoking history

1.826

0.459–7.260

0.392

   

IL-2

1.053

0.850–1.305

0.638

   

IL-4

1.032

0.930–1.145

0.550

   

IL-5

1.526

0.793–2.937

0.206

   

IL-6

1.044

1.017–1.072

0.001***

1.121

1.015–1.239

0.024*

IL-8

1.002

1.001–1.004

0.011*

1.006

0.999–1.012

0.074

IL-10

1.076

0.946–1.224

0.264

   

IL-1β

1.023

0.962–1.089

0.469

   

IL-17A

1.027

0.985–1.070

0.218

   

IL-12p70

0.997

0.832–1.195

0.976

   

TNF-α

1.014

0.994–1.034

0.159

1.050

0.995–1.108

0.077

IFN-α

1.105

0.923–1.322

0.277

   

IFN-γ

1.080

0.879–1.326

0.464

   

LDH, U/L

1.008

1.002–1.014

0.007**

1.009

0.995–1.024

0.197

CRP, mg/L

1.013

0.995–1.031

0.161

0.959

0.914–1.006

0.086

ESR, mm/h

1.011

0.992–1.031

0.268

   

NLR

1.102

0.975–1.245

0.120

0.809

0.354–1.850

0.616

RDW %

1.066

0.771–1.474

0.698

   

TBil, umol/L

1.095

0.971–1.235

0.140

1.865

1.008–3.450

0.047*

CD3 + CD4 + T cells

0.998

0.996–1.000

0.042*

0.983

0.968–0.999

0.037*

sPAH, mmHg

1.017

0.965–1.072

0.527

   

PaO2/FiO2 ratio

0.986

0.979–0.994

0.001***

0.985

0.966–1.004

0.123

  1. LDH, lactate dehydrogenase; NLR, neutrophil-to-lymphocyte ratio; RDW, red cell distribution width; sPAH, systolic pulmonary artery pressure; PaO2/FiO2: partial arterial oxygen pressure/inspired oxygen fraction; GGO, ground-glass opacity. OR, odds ratio; CI, confidence interval
  2. *P < 0.05, **P < 0.01, ***P < 0.001