Table 6 Comparison of cytokine levels between anti-MDA5-positive and anti-MDA5-negative patients in PM/DM
Variables | Anti-MDA5-positive PM/DM-ILD (n = 8), pg/mL | Anti-MDA5-negative PM/DM-ILD (n = 6), pg/mL | P value |
|---|---|---|---|
IL-2 | 0.5 (0.2–1.3) | 1.6 (1.1–2.4) | 0.081 |
IL-4 | 1.1 (0.3–1.4) | 3.2 (1.5–3.8) | 0.020* |
IL-5 | 0.4 (0.3–1.1) | 1.1 (0.8–1.4) | 0.181 |
IL-6 | 26.5 (8.8–58.1) | 5.7 (5.2–12.3) | 0.142 |
IL-8 | 197.2 (27.5–648.5) | 41.8 (15.4–110.3) | 0.181 |
IL-10 | 4.1 (3.2–6.8) | 5.4 (4.5–8.1) | 0.491 |
IL-1β | 3.0 (2.2–6.7) | 6.0 (4.1–7.9) | 0.181 |
IL-17A | 9.7 (6.6–13.1) | 10.6 (6.1–22.8) | 0.662 |
IL-12p70 | 2.3 (1.3–3.2) | 5.0 (3.8–6.6) | 0.020* |
TNF-α | 4.7 (1.5–18.2) | 4.4 (3.0–5.8) | 0.950 |
IFN-α | 5.3 (1.5–10.4) | 4.2 (2.0–8.5) | 0.852 |
IFN-γ | 3.1 (1.5–6.7) | 5.4 (2.2–6.4) | 0.414 |