Table 1 Retrospective case series of adverse events during or following WBC
First author (year) | Number of cases | Preexisting risk factor | Latency of AE onset | Nature of AE | Gravity of AE (grade) | Recovery time | Evidence for causality |
|---|---|---|---|---|---|---|---|
Greenwald [22] | 1 | Neutropenia | A few days | Cold panniculitis | Minor (grade 2) | Several weeks | Possible |
Carrard [20] | 1 | Work-related stress | Right after WBC | Global amnesia | Serious (grade 3) | 24 h | Possible |
Cronier [23] | 1 | Ocular migraine | Right after WBC | Cerebral bleeding | Serious (grade 4) | 3 months | Probable |
Chen [24] | 1 | None | Right after WBC | Moyamoya synd | Serious (grade 3) | 1 month | Probable |
Camara [21] | 1 | Hypertension | One week | Aortic dissection | Serious (grade 4) | 2–3 months | Probable |
Happe [25] | 2 | NR | During study | Headache | Minor (grade 1) | NR | Convincing |
Hirvonen [26] | 4 | NR | During study | Discomfort/dizz | Minor (grade 1) | NR | Convincing |
Hirvonen [26] | 1 | NR | During study | Hypertension | Minor (grade 1) | NR | Convincing |
Hirvonen [26] | 2 | NR | During study | Lasting shivering | Minor (grade 1) | NR | Convincing |
Hirvonen [26] | 1 | NR | During study | Headache | Minor (grade 1) | NR | Convincing |
Hirvonen [26] | 1 | NR | During study | Urticaria | Minor (grade 1) | NR | Convincing |