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Table 1 Baseline demographics and clinical characteristics of 776 cases of non-radiographic axial spondyloarthritis*

From: Comparison of clinical characteristics between adult-onset and juvenile-onset non-radiographic axial spondyloarthritis in Chinese patients: results from the COCAS cohort

Parameter

 

Total

(n = 776)

Male

(n = 433)

Female

(n = 343)

P†

Age at disease onset, (yrs), Median (IQR)

 

22.0 (11.0)

19.0 (10.0)

24.0 (10.0)

 < 0.001#

Age at first visit, (yrs), Median (IQR)

 

24.0 (13.0)

22.0 (12.0)

27.0 (12.0)

 < 0.001#

Baseline disease duration, (yrs), Median (IQR)

 

2.0 (3.5)

2.0 (3.5)

2.0 (4.5)

0.574#

HLA-B27 positive

 

560 (72.2)

341 (78.8)

219 (63.8)

 < 0.001

Family history of SpA

 

129 (16.6)

76 (17.6)

53 (15.5)

0.435

Initial symptoms

Axial

435 (56.1)

234 (54.0)

201 (58.6)

0.204

Peripheral

326 (42.0)

190 (43.9)

136 (39.7)

0.236

Extra-articular

16 (2.1)

9 (2.1)

7 (2.0)

0.971

Symptom, ever

Axial only

194 (25.0)

98 (22.6)

96 (28.0)

0.087

Peripheral

582 (75.0)

335 (77.4)

247 (72.0)

0.087

Lower limbs

398 (51.3)

228 (52.7)

170 (49.6)

0.392

Upper limbs

167 (21.5)

81 (18.7)

86 (25.1)

0.032

Extra-articular

81 (10.4)

43 (9.9)

38 (11.1)

0.603

Spinal pain (baseline), 0–10 NRS, Median (IQR)‡

 

5.0 (2.0)

5.0 (2.0)

5.0 (2.0)

0.488

Patient’s global assessment (baseline), 0–10 NRS, Median (IQR)‡

 

6.0 (2.0)

6.0 (2.0)

6.0 (2.0)

0.002

Pain/swelling peripheral joints (baseline), 0–10 NRS, Median (IQR)‡

 

3.0 (5.0)

3.0 (6.0)

3.0 (5.0)

0.116

Duration of morning stiffness (baseline), 0–10 NRS, Median (IQR)‡

 

1.0 (3.0)

2.0 (3.0)

1.0 (3.0)

0.140

Elevated ESR (baseline)

 

328 (42.3)

209 (48.3)

119 (34.7)

 < 0.001

Elevated CRP (baseline)

 

314 (40.5)

213 (49.2)

101 (29.4)

 < 0.001

ASDAS-ESR (baseline), Median (IQR)‡

 

2.7 (1.3)

2.7 (1.4)

2.6 (1.2)

0.170#

ASDAS-CRP (baseline), Median (IQR)‡

 

2.7 (1.3)

3.0 (1.5)

2.4 (1.1)

 < 0.001#

ASDAS-ESR (baseline) > 2.1‡

 

372 (74.3)

211 (74.8)

161 (73.5)

0.740

ASDAS-CRP (baseline) > 2.1‡

 

377 (75.2)

225 (80.1)

152 (69.1)

0.005

SIJ-MRI positivity, n (%)§

 

383 (58.4)

206 (56.9)

177 (60.2)

0.394

Medications

 NSAIDs monotherapy

 

382 (49.2)

206 (47.6)

176 (51.3)

0.301

 NSAIDs + csDMARDs

 

313 (40.3)

167 (38.6)

146 (42.6)

0.260

 NSAIDs + bDMARDs

 

81 (10.4)

60 (13.9)

21 (6.1)

 < 0.001

  1. HLA-B27 = human leukocyte antigen B27; SpA = spondyloarthritis; NRS = numerical rating scale; ASDAS-CRP = Ankylosing Spondylitis Disease Activity Score; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate; MRI-SIJ = MRI of the sacroiliac joints; NSAIDs = non-steroidal anti-inflammatory drugs; csDMARDs = conventional synthetic disease-modifying anti-rheumatic drugs; bDMARDs = biological disease-modifying anti-rheumatic drugs
  2. Bold values indicate statistical significance with P value less than 0.05
  3. *Values are the n (%) unless otherwise indicated. † Chi-square test was used to compare male and female patients unless otherwise indicated
  4. #Mann–Whitney U test
  5. ‡Available in 501 patients (n = 281 for male and n = 220 for female)
  6. §Available in 656 patients (n = 362 for male and n = 294 for female)
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European Journal of Medical Research

ISSN: 2047-783X

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