Table 6 Multivariable Cox regression analysis of factors associated with survival of patients

Pre-therapy tumor size (cm)

 ≥ 5 vs. < 5

2.091 (1.176–3.715)

1.821 (1.050–3.156)

Clinical TNM stage

III/IVA vs. IIA/IIB

1.488 (0.611–2.436)

1.628 (0.925–2.864)

NAC

Yes vs. no

0.245 (0.103–0.811)

0.591 (0.364–0.958)

Histological grade

Poorly vs. well/moderate

-

1.905 (1.125–3.328)

Pathological T stage

T3/4a/4b vs. T0/1/2

2.266 (0.997–3.124)

1.607 (0.974–2.652)

Pathological N stage

N-positive vs. N-negative

1.111 (0.677–1.821)

1.109 (0.599–2.052)

Lymphovascular invasion

Yes vs. no

1.372 (0.917–1.821)

1.984 (1.254–2.796)

Pathological TNM stage

III/IV vs. 0/I/II

1.992 (1.062–3.736)

2.233 (1.198–4.162)