Factors influencing the degree of disability in patients with neuromyelitis optica spectrum disorders

Table 1 Univariate analysis of the degree of disability in NMOSD patients

Index	< 7 (n = 66)	≥ 7 (n = 18)	t/z/χ2	P
EDSS score	4.50 (4.00, 5.00)	7.00 (6.87, 8.12)	−6.603^c	0.000^**
Age	43.11 ± 13.63	43.22 ± 12.41	−0.33^a	0.731
Men/women ratio	11/55	3/15	0.000^b	1.000
UA umol/L	249.28 ± 76.53	239.39 ± 88.32	0.470^a	0.742
TBil umol/L	11.23 (8.09, 14.02)	7.72 (6.64, 10.39)	−2.960^c	0.003^**
DBil umol/L	3.27 (2.28, 4.53)	2.58 (2.08, 3.83)	−1.248^c	0.212
ALB g/L	37.72 ± 3.70	36.35 ± 2.79	1.460^a	0.856
IgG g/L	10.15 (8.04, 13.72)	10.75 (7.54, 13.95)	−0.349^c	0.727
CSF ALB mg/dl	17.25 (13.41, 27.07)	22.99 (18.76, 39.94)	−2.333^c	0.02^*
CSF IgG mg/dl	2.87 (1.93, 5.14)	6.05 (2.74, 10.65)	−2.398^c	0.016^**
QALB	4.7 (3.5, 7.7)	6.3 (5.5, 11.2)	−2.524^c	0.012^**
QIgG	2.8 (2.0, 4.5)	4.7 (2.9, 7.1)	−2.660^c	0.008^**
24 h intrathecal synthesis rate	3.0 (1.45, 6.96)	5.24 (1.90, 11.52)	−1.157^c	0.116
Visual impairment	39/27	8/10	1.231^b	0.267

The univariate analysis showed that TBil, CSF ALB, CSF IgG, QALB, and QIgG levels in the EDSS score ≥ 7 group were significantly different from those in the EDSS score < 7 group (P < 0.05)
^*P < 0.05, ^**P < 0.01
^aThe t-value from the independent sample t-test
^bThe χ²-value from the χ²test
^cThe Z-value from the Mann–Whitney U test

ISSN: 2047-783X