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Table 1 Characteristics of the included studies

From: Sleep disturbance increases the risk of severity and acquisition of COVID-19: a systematic review and meta-analysis

Author

Year

Country

Type of study

Sample size

Study population

Age

Male (%)

Sleep quality measure

Ahmadi [15]

2021

UK

Cohort study

468,569

Adults aged between 40 and 69 years from the UK Biobank

56.5 ± 8.1

45.40%

5-point scale based on: Morning chronotype, sleep duration (7–9 h), not usually insomnia, no snoring, and no frequent daytime sleepiness

Poor sleep = 0 or 1 moderate sleep = 2 or 3 good sleeps = 4 or 5

Cloosterman [16]

2021

Netherlands

Cohort study

2586

Runners participating in an ongoing randomized controlled trial on running injury prevention among recreational runners

44.4 (12.2)

62

On five option scale for sleep disruption from 5 (strongly agree) to 1 (strongly disagree), sleep disruption was categorized as an answer of agree or strongly agree (4 or 5 points)

Elise [17]

2022

UK

Panel study (Longitudinal study)

1811

Adults from the UCL COVID-19 Social Study who had previously been infected with COVID-19

45–59 = 40.70%

30–44 = 23.91% 18–29 = 5.96%

24.41

5 option scale from very good, good, average, not good, and very poor

Good sleep was categorized as very good/good, average sleep as average and poor sleep as not good/very poor

Gao [18]

2020

China

Case–control

105 cases and 210 controls

Patients with SARS-CoV-2 infection as the case group from the Wuhan Tongji Hospital, and 2 controls for each case from communities in Wuhan

54.3 (55 for case and 54 for control)

45.70%

Lack of sleep referred to sleep duration < 7 h per night. (Sleep duration = (5 × weekday sleep duration) + (2 × weekend sleep duration)/7)

Hayley [19]

2021

UK

Cohort study

15,227

Age 16 years or more and residence in the UK at the point of enrolment, recruited via a national media campaign

59.4 ± 13.4

30.2

Online questions asking about sleep hours

Huang [20]

2020

China

Cohort study

164

A history of SARS-CoV-2 infection confirmed by high-throughput sequencing or positive real-time reverse-transcription polymerase-chain-reaction, Chinese race, and age ≥ 18 years and discharged from one of 4 clinical centers in 3 provinces

44

50

Sleep status was defined according to national sleep foundation guidelines

Hyunju [21]

2021

USA

Case–control

568 COVID-19 cases and 2316 controls

Healthcare workers in 6 countries with a high frequency of workplace exposure to covid-19

48

71.6

The following 3 sleep problems were defined: (1) Did you have difficulties falling asleep at night? (2) Did you often wake up in the early hours, unable to get back to sleep? (3) Did you take sleeping pills more than 3 times per week? A score between 0 and 3 was given based on having these sleep problems

Jones et al. [22]

2022

USA

Cohort study

557,000

Individuals in the FInnGen database

N.R

N.R

ICD10-based electronic health record

and questionnaire-based information

on self-reported short sleep and insomnia

and diagnosis of insomnia

Li et al. [23]

2021

USA

Cohort study

46,535

UK biobank

69.4 ± 8.3 years

46.70%

Sleep behavior burdens:

“none” (0),

“mild” (1),

“moderate” (2–3),

“significant” (4–6)

Marcus et al. [24]

2021

USA

Cohort study

14,335

English speaking adults with a smartphone

18–29 years: 1961 (13.7%)

30–39 years: 3225 (22.5%)

40–49 years: 2873 (20.0%)

50–59 years: 2839 (19.8%)

 + 60 years: 3437 (24.0%)

35%

Sleep duration

Mohsin et al. [25]

2021

Bangladesh

Comparative cross-sectional

1500

COVID-19 patients in Dhaka city

43.23 ± 15.48 years

69.20%

History of sleep disturbances

Pływaczewska et al. [26]

2022

Poland

Cohort study

1847

Participants of the STOP-COVID registry of the PoLoCOV-Study

Median age 51

34.50%

History of insomnia (defined as a difficulty falling asleep and maintaining sleep continuity during 4 weeks before COVID-19; falling asleep after midnight and nightshift work)