Table 3 Diagnostic performance of soluble checkpoint and laboratory indexes in predicting PBC severity
From: Soluble immune checkpoints are elevated in patients with primary biliary cholangitis
Cutoff | AUC | Sensitivity% | Specificity% | ||
|---|---|---|---|---|---|
The diagnostic performance between HC and PBC | PD-L1 | 68 | 0.9704 (0.9399 to 1.001) | 100 | 90 |
CD134 | 89.15 | 0.9667 (0.9235 to 1.010) | 89.47 | 96.67 | |
PD-1 | 213.4 | 0.9219 (0.8157 to 1.028) | 89.47 | 96.67 | |
LAG-3 | 1.05 | 0.8373 (0.7383 to 0.9363) | 84.21 | 80 | |
TIM-3 | 252.7 | 0.7925 (0.6597 to 0.9253) | 65 | 86.67 | |
γGT | 85 | 0.9577 (0.9176 to 0.9978) | 100 | 82.14 | |
ALP | 92.35 | 0.9591 (0.9172 to 1.001) | 89.47 | 91.07 | |
TBIL | 15.75 | 0.6774 (0.5570 to 0.7978) | 78.57 | 65 | |
The diagnostic performance between early (stage I-II) and late (stage III-IV) PBC | CD134 | 199.45 | 0.767 (0.623 to 0.911) | 78.9 | 62.9 |
TIM-3 | 361.5 | 0.765 (0.638 to 0.893) | 78.9 | 65.7 | |
PD-1 | 302.6 | 0.669 (0.519 to 0.821) | 78.9 | 51.4 | |
PD-L1 | 116.65 | 0.681 (0.531 to 0.832) | 63.2 | 74.3 | |
LAG-3 | 1.35 | 0.594 (0.431 to 0.757) | 73.68 | 45.71 | |
γGT | 622 | 0.5028 (0.3254 to 0.6802) | 25 | 87.88 | |
ALP | 100 | 0.518 (0.3335 to 0.7024) | 25 | 93.94 | |
TBIL | 28.6 | 0.875 (0.7709 to 0.9791) | 87.5 | 82.86 |