Fig. 2From: Crosstalk between autophagy and insulin resistance: evidence from different tissuesMolecular mechanism of lipophagy. Under nutrient deprivation, lipophagy forms phagophores. Patatin-like phospholipase domain-containing enzyme (PNPLA) interacts with LDs and performs critical functions in the breakdown of LDs. Autophagosomes engulf LDs and fuse with a lysosome to form an autolysosome. Then, lysosomal lipases hydrolyze the neutral lipids of LDsBack to article page