Fig. 3

Effects of osteoclast‐specific knockout of PDK1 on prostate cancer-induced osteolysis. A Anatomy of bone metastases from prostate cancer in PDK1 cKO and WT mice. B Comparison of tumor mass between PDK1 cKO and WT mice. C, D, F, G, I, J Bone parameter analysis. SMI, structural model index; Conn-dens., connectivity density; Tb. Sp, trabecular separation; Tb. N, trabecular number; Tb. Th, trabecular thickness; BV/TV, bone volume fraction. E Three-dimensional reconstruction of the tibia; scale bar = 1 mm. H HE and TRAP staining of tibia sections; scale bar = 200 μm. N = 6, all of the data are presented as the mean ± SD. ^NSP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001