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Fig. 6 | European Journal of Medical Research

Fig. 6

From: Conditional knockout of PDK1 in osteoclasts suppressed osteoclastogenesis and ameliorated prostate cancer-induced osteolysis in murine model

Fig. 6

The mechanisms of PDK1 in osteoclast formation. PDK1 positively regulated osteoclast formation through the RANKL-induced NF-κB signaling pathway. M-CSF, macrophage colony stimulating factor; PDK1, 3-phosphoinositide-dependent protein kinase-1; MAPK, mitogen‐activated protein kinase; NF‐κB, nuclear factor κ‐light‐chain enhancer of activated B cells; NFATc1, nuclear factor of activated T cells 1

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European Journal of Medical Research

ISSN: 2047-783X

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