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Table 3 Blood levels of markers of the neuro-endocrine and inflammatory stress response over time and the effect of type of anesthesia

From: The effect of spinal versus general anaesthesia on perioperative muscle weakness in patients having bilateral total hip arthroplasty: a single center randomized clinical trial

  

Pre-OP

End of surgery

Post-OP D1

ACTH (ng/l)

GA

32.9 (5.8)

72.8 (17.9)

27.5 (7.1)

SA

34.7 (6.3)

27.1 (8.8)

18.9 (5.8)

p-value

0.83

0.003

0.32

Cortisol (µg/dl)

GA

12.9 (0.9)

19.2 (1.3)

14.8 (1.8)

SA

12.4 (1.1)

8.6 (1.1)

13.2 (1.7)

p-value

0.70

< 0.0001

0.55

IL-6 (ng/l)

GA

6.24 (2.4))

43.08 (13)

369.8 (40.2)

SA

3.45 (0.4)

15.81 (4.2)

345.1 (56.2)

p-value

0.19

0.002

0.41

  1. Mean values and standard deviations of ACTH, Cortisol and IL-6 are shown on different time points for the different types of anaesthesia. p-values indicate the relative difference between the two types of anaesthesia on the different time points
  2. ACTH adrenocorticotropic hormone, IL-6 interleukin-6, GA general anaesthesia, SA spinal anesthesia