Fig. 3

Expression and functional regulation of PLAC8 mediated by m6A modification. A The m6A levels of GGACU (Position 405) (Site1) and GAACU (Position 1449) (Site2) in HTR-8/SVneo cells treated with hypoxia were detected. B, C PLAC8 expression was detected by qRT-PCR and Western blot. D, E Transwell was performed to detect migration and invasion. F Protein levels of MMP-2 and MMP-9 in HTR-8/Svneo cells were detected by western blot. G The secretion levels of MMP-2 and MMP-9 in HTR-8/Svneo cells were detected by ELISA. ^ns p > 0.05, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001