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Table 5 Association between HOMA-IR and Biological Age, Adjusted for Covariates

From: HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Variable

Model 1

Model 2

Model 3

Model 4

β (95%)

P-value

β (95%)

P-value

β (95%)

P-value

β (95%)

P-value

HOMA-IR

0.8 (0.7,1.0)

 < 0.001

0.9 (0.8,1.0)

 < 0.001

0.6 (0.5,0.7)

 < 0.001

0.5 (0.4,0.6)

 < 0.001

HOMA-IR group

 

 Q1

0 (Ref)

0 (Ref)

0 (Ref)

0 (Ref)

 Q2

2.8 (1.9,3.8)

 < 0.001

3.0 (2.1,3.9)

 < 0.001

1.8 (1.0,2.6)

 < 0.001

2.1 (1.3,3.0)

 < 0.001

 Q3

5.7 (4.7,6.6)

 < 0.001

6.1 (5.2,7.1)

 < 0.001

4.0 (3.1,4.9)

 < 0.001

4.1 (3.1,5.2)

 < 0.001

 Q4

9.6 (8.6,10.5)

 < 0.001

10.0 (9.1,11.0)

 < 0.001

7.0 (6.3,7.8)

 < 0.001

6.9 (6.0,7.9)

 < 0.001

 P for trend

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

  1. Model 1: Non-adjusted
  2. Model 2: Adjusted for sex, ethnic
  3. Model 3: Adjusted for Model2 + Marital status, PIR, smoking, alcohol use
  4. Model 4: Adjusted for Model3 + BMI, ALT, AST, TG, HDL