HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Table 8 Stratified associations between HOMA-IR and Advanced Aging, Adjusted for Covariates

Characteristic	No. of participants	OR (95% CI)	P	P for interaction
Sex				0.001
Male	6343	1.1 (1.0,1.1)	< 0.001
Female	5923	1.1 (1.1,1.1)	< 0.0001
Smoke				0.3
Former	3241	1.1 (1.0,1.1)	< 0.001
Never	6445	1.1 (1.0,1.1)	0.002
Now	2569	1.1 (1.1,1.2)	< 0.0001
BMI				0.02
< 18.5	181	1.3 (0.5, 3.2)	0.5
≥ 18.5, < 24	2626	1.2 (1.1,1.4)	< 0.001
≥ 24, < 28	3509	1.1 (1.0,1.1)	0.01
≥ 28	5780	1.1 (1.0,1.1)	< 0.0001
Ethnic				0.5
Mexican American	2589	1.1 (1.0,1.2)	< 0.001
Non-Hispanic Black	2173	1.1 (1.0,1.1)	0.01
Non-Hispanic White	6182	1.1 (1.0,1.1)	< 0.0001
Other Hispanic	838	1.2 (1.1, 1.3)	0.004
Other Race	484	1.0 (0.9, 1.2)	0.6
Alcohol use				0.2
Former	2389	1.0 (1.0,1.1)	0.1
Heavy	2703	1.1 (1.0,1.1)	0.001
Mild	3787	1.1 (1.0,1.1)	0.01
Moderate	1586	1.1 (1.0,1.2)	0.01
Never	1631	1.1 (1.0,1.2)	0.01

Model adjusted for sex, BMI, smoke, ethnic, alcohol use, mar, PIR, ALT, AST, TG, HDL
In each case, the model is not adjusted for the stratification variable

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