Characteristics | Total (n = 1049) | Quartiles of MHR | P value | |||
---|---|---|---|---|---|---|
Quartile 1 (n = 265) MHR  < 0.33 (× 109/mmol) | Quartile2 (n = 261) 0.33 ≤ MHR  < 0.46 (× 109/mmol) | Quartile3 (n = 261) 0.46 ≤ MHR < 0.62 (× 109/mmol) | Quartile4 (n = 262) 0.62 ≥ MHR (× 109/mmol) | |||
Gender, n (%) | Â | Â | Â | Â | Â | Â |
 Male | 813 (75.5) | 222 (61.7) | 280 (77.8) | 311 (86.4) | 224 (85.5) |  < 0.001 |
 Female | 267 (24.7) | 138 (38.3) | 80 (22.2) | 49 (13.6) | 38 (14.5) |  |
Age (years) | 61.4 ± 10.7 | 62.2 ± 9.7 | 61.7 ± 10.9 | 60.9 ± 10.2 | 60.7 ± 11.9 | 0.307 |
Vital sigh | Â | Â | Â | Â | Â | Â |
 SBP (mmHg) | 124.8 ± 18.6 | 127.3 ± 18.6 | 124.5 ± 20.2 | 124.8 ± 18.5 | 122.4 ± 16.8 | 0.028 |
 DBP (mmHg) | 73.3 ± 12.1 | 74.0 ± 13.0 | 72.7 ± 12.0 | 74.2 ± 12.5 | 72.1 ± 10.7 | 0.114 |
 HR (bpm) | 74.4 ± 10.3 | 74.4 ± 10.3 | 73.5 ± 10.9 | 74.8 ± 10.7 | 74.9 ± 11.3 | 0.418 |
Body mass index(kg/m2) | 28.9 ± 1.0 | 29.4 ± 0.9 | 29.1 ± 0.7 | 28.8 ± 0.7 | 28.2 ± 1.3 |  < 0.001 |
Comorbidities, n (%) | Â | Â | Â | Â | Â | Â |
 Hypertension | 714 (68.1) | 186 (70.2) | 168 (64.4) | 179 (68.6) | 181 (69.1) | 0.503 |
 Hypercholesterolemia | 793 (75.6) | 189 (71.3) | 196 (75.1) | 199 (76.3) | 209 (79.8) | 0.158 |
 Renal insufficiency | 510 (48.6) | 134 (50.6) | 128 (49.0) | 122 (46.7) | 126 (48.1) | 0.845 |
 Atrial fibrillation | 57 (5.4) | 14 (5.3) | 15 (5.8) | 17 (6.5) | 11 (4.2) | 0.698 |
History, n (%) | Â | Â | Â | Â | Â | Â |
 Prior MI | 250 (23.8) | 68 (25.7) | 60 (23.0) | 62 (23.8) | 60 (22.9) | 0.869 |
 Prior PCI | 124 (11.8) | 30 (11.3) | 34 (13.0) | 34 (13.0) | 26 (9.9) | 0.638 |
 Prior stroke | 134 | 33 | 38 | 27 | 36 | 0.499 |
NYHA class, n (%) | Â | Â | Â | Â | Â | Â |
 I | 102 (9.7) | 29 (10.9) | 24 (9.2) | 30 (11.5) | 19 (7.3) | 0.626 |
 II | 576 (54.9) | 143 (54.0) | 147 (56.3) | 145 (55.6) | 141 (53.8) |  |
 III | 332 (31.7) | 87 (32.8) | 79 (30.3) | 77 (29.5) | 89 (34.0) |  |
 IV | 39 (3.7) | 6 (2.3) | 11 (4.2) | 9 (3.5) | 13 (3.7) |  |
Echocardiography | Â | Â | Â | Â | Â | Â |
 LVDs (millimetre) | 39.9 ± 7.8 | 39.5 ± 7.3 | 40.5 ± 8.0 | 39.5 ± 8.0 | 40.1 ± 7.9 | 0.414 |
 LVDd (millimetre) | 53.9 ± 6.8 | 53.3 ± 6.2 | 54.4 ± 7.2 | 53.9 ± 7.0 | 53.9 ± 6.9 | 0.375 |
 LVEF (%) | 44.7 ± 9.5 | 44.9 ± 9.1 | 44.3 ± 9.4 | 45.9 ± 9.9 | 43.7 ± 9.1 | 0.054 |
Angiographic data, n (%) | Â | Â | Â | Â | Â | Â |
 LM disease | 197 (18.8) | 43 (16.2) | 54 (20.7) | 47 (18.0) | 53 (20.2) | 0.528 |
 Three‑vessel disease | 611 (58.3) | 141 (53.2) | 159 (60.9) | 156 (59.8) | 155 (59.2) | 0.289 |
 Chronic total occlusion | 295 (28.1) | 67 (25.3) | 77 (29.5) | 73 (28.0) | 78 (29.8) | 0.646 |
 Diffuse lesion | 205 (19.5) | 49 (18.5) | 45 (17.2) | 55 (21.1) | 56 (21.418) | 0.570 |
 In-stent restenosis | 55 (5.2) | 18 (6.8) | 12 (4.6) | 13 (5.0) | 12 (4.6) | 0.622 |
 SYNTAX score | 22.0 ± 7.9 | 21.0 ± 7.1 | 22.4 ± 8.4 | 22.2 ± 7.6 | 22.5 ± 8.3 | 0.121 |
Procedural results | Â | Â | Â | Â | Â | Â |
 Target vessel territory, n (%) |  |  |  |  |  |  |
  LM | 177 (16.9) | 39 (14.7) | 49 (18.8) | 44 (16.9) | 45 (17.2) | 0.667 |
  LAD | 779 (74.3) | 195 (73.6) | 200 (76.6) | 189 (72.4) | 195 (74.4) | 0.730 |
  LCX | 685 (65.3) | 171 (64.5) | 166 (63.6) | 164 (62.8) | 184 (70.2) | 0.271 |
  RCA | 710 (67.7) | 175 (66.0) | 185 (70.9) | 184 (70.5) | 166 (63.4) | 0.192 |
 Complete revascularization, n (%) | 624 (59.5) | 165 (62.3) | 162 (62.1) | 148 (56.7) | 149 (56.9) | 0.369 |
 Number of stents | 3.3 ± 1.5 | 3.3 ± 1.4 | 3.4 ± 1.4 | 3.4 ± 1.6 | 3.3 ± 1.5 | 0.571 |
Laboratory parameters | Â | Â | Â | Â | Â | Â |
 Glucose (mmol/L) | 9.0 ± 3.5 | 8.5 ± 3.2 | 9.1 ± 3.5 | 9.1 ± 3.4 | 9.3 ± 3.7 | 0.057 |
 HbA1c (%) | 7.9 ± 1.4 | 7.8 ± 1.5 | 7.9 ± 1.4 | 7.9 ± 1.4 | 8.0 ± 1.4 | 0.457 |
 GA (%) | 20.7 ± 5.2 | 20.7 ± 5.3 | 20.7 ± 5.3 | 20.7 ± 5.3 | 20.6 ± 5.1 | 0.990 |
 BNP (pg/ml) | 334 (144,507) | 308 (135,478) | 300 (144,487) | 337 (150,484) | 373 (147,577) | 0.164 |
 FBG (mg/dL) | 3.6 ± 1.0 | 3.4 ± 0.7 | 3.5 ± 0.8 | 3.6 ± 1.0 | 3.9 ± 1.2 |  < 0.001 |
 D-dimer | 138 (87,204) | 138 (83,193) | 138 (84,191) | 138 (81,212) | 138 (103,226) | 0.014 |
 INR | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 | 0.008 |
 TC (mmol/L) | 4.0 ± 1.1 | 4.02 ± 1.1 | 4.0 ± 1.1 | 3.9 ± 1.1 | 3.9 ± 1.1 | 0.005 |
 Triglyceride (mg/dL) | 1.8 ± 1.3 | 1.7 ± 1.2 | 1.8 ± 1.3 | 1.9 ± 1.1 | 2.1 ± 1.6 | 0.003 |
 LDL-C (mmol/L) | 2.4 ± 0.9 | 2.4 ± 1.0 | 2.4 ± 0.9 | 2.4 ± 0.9 | 2.3 ± 0.8 | 0.223 |
 HDL-C (mmol/L) | 1.0 ± 0.2 | 1.2 ± 0.3 | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.2 |  < 0.001 |
 Total bilirubin (mg/dL) | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.7 ± 0.3 | 0.8 ± 0.4 | 0.7 ± 0.3 | 0.635 |
 Direct bilirubin (μmol/L) | 4.1 ± 2.0 | 3.8 ± 1.9 | 4.2 ± 2.1 | 4.0 ± 2.0 | 4.2 ± 2.1 | 0.099 |
 ALT (U/L) | 21 (15,32) | 21 (14,29) | 21 (14,31) | 22 (14,31) | 23 (15,38) | 0.012 |
 AST (U/L) | 20 (16,30) | 20 (16,27) | 19 (15,26) | 20 (16,30) | 24 (16,44) | 0.002 |
 ALP (U/L) | 78.4 ± 24.7 | 79.5 ± 24.5 | 78.5 ± 28.7 | 78.9 ± 23.0 | 77.0 ± 22.2 | 0.686 |
 GGT (U/L) | 30.7 ± 17.4 | 28.8 ± 17.0 | 31.0 ± 18.0 | 33.6 ± 19.1 | 29.5 ± 14.8 | 0.009 |
 Creatinine (mg/dL) | 1.0 ± 0.9 | 1.0 ± 1.0 | 1.0 ± 0.9 | 1.0 ± 0.8 | 1.1 ± 1.0 | 0.305 |
 Blood nitrogen urea (mg/dL) | 7.1 ± 3.5 | 7.0 ± 2.9 | 7.1 ± 4.1 | 7.1 ± 3.5 | 7.2 ± 3.6 | 0.967 |
 eGFR (mL/min × 1.73 m2) | 82.9 ± 24.5 | 83.2 ± 23.4 | 83.8 ± 24.5 | 83.9 ± 22.6 | 80.9 ± 27.2 | 0.455 |
 Uric acid (μmol/L) | 362.5 ± 104.5 | 340.6 ± 92.6 | 358.6 ± 100.4 | 372.0 ± 112.3 | 379.0 ± 108.2 |  < 0.001 |
 Sodium (mmol/L) | 138.8 ± 3.0 | 138.9 ± 2.9 | 139.1 ± 3.1 | 138.8 ± 2.8 | 138.7 ± 3.2 | 0.487 |
 Potassium (mmol/L) | 4.2 ± 0.5 | 4.2 ± 0.4 | 4.3 ± 0.5 | 4.2 ± 0.4 | 4.1 ± 0.5 | 0.013 |
 Calcium (mmol/L) | 2.3 ± 0.1 | 2.3 ± 0.1 | 2.3 ± 0.1 | 2.3 ± 0.1 | 2.3 ± 0.1 |  < 0.001 |
 Magnesium (mmol/L) | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.105 |
 White blood cell (109/L) | 7.8 ± 2.4 | 6.6 ± 2.0 | 7.3 ± 1.7 | 7.9 ± 1.8 | 9.4 ± 3.0 |  < 0.001 |
 Haemoglobin (g/dL) | 134.8 ± 19.4 | 132.4 ± 19.8 | 135.3 ± 18.8 | 136.0 ± 19.2 | 135.5 ± 19.5 | 0.135 |
 Monocyte (109/L) | 0.5 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.7 ± 0.2 |  < 0.001 |
 Platelet (109/L) | 221.5 ± 66.0 | 210.8 ± 67.1 | 215.3 ± 62.0 | 220.6 ± 61.3 | 239.6 ± 69.7 |  < 0.001 |
 hs-CRP | 6.1 ± 7.9 | 3.3 ± 5.5 | 4.7 ± 6.9 | 6.8 ± 8.0 | 9.9 ± 9.0 |  < 0.001 |
 MHR (109/mmol) | 0.51 ± 0.25 | 0.26 ± 0.05 | 0.40 ± 0.03 | 0.54 ± 0.05 | 0.84 ± 0.22 |  < 0.001 |
Medication use, n (%) | Â | Â | Â | Â | Â | Â |
 Aspirin | 1043 (99.4) | 265 (100.0) | 259 (99.2) | 258 (98.9) | 261 (99.6) | 0.335 |
 Clopidogrel | 869 (82.8) | 224 (84.5) | 222 (85.1) | 213 (81.6) | 210 (80.2) | 0.385 |
 Ticagrelor | 180 (17.2) | 41 (15.5) | 39 (14.9) | 48 (18.4) | 52 (19.9) | 0.385 |
 Statins | 1038 (99.0) | 265 (100.0) | 256 (98.1) | 258 (98.9) | 259 (98.9) | 0.191 |
 Ezetimibe | 268 (25.6) | 58 (21.9) | 73 (28.0) | 71 (27.2) | 66 (25.2) | 0.382 |
 ACEI | 90 (8.6) | 26 (9.8) | 21 (8.1) | 16 (6.1) | 27 (10.3) | 0.308 |
 ARB | 147 (14.0) | 37 (14.0) | 28 (10.7) | 48 (18.4) | 34 (13.0) | 0.081 |
 Beta-blockers | 641 (61.1) | 151 (57.0) | 150 (57.5) | 165 (63.2) | 175 (66.8) | 0.060 |
 CCB | 200 (19.1) | 52 (19.6) | 55 (21.1) | 55 (21.1) | 38 (14.5) | 0.176 |
 Diuretics |  |  |  |  |  |  |
  Loop diuretics | 630 (60.1) | 150 (56.6) | 146 (55.9) | 147 (56.3) | 187 (71.4) |  < 0.001 |
  Thiazide diuretics | 61 (5.8) | 20 (7.6) | 13 (5.0) | 17 (6.5) | 11 (4.2) | 0.352 |
  Spironolactone | 494 (47.1) | 124 (46.8) | 118 (45.2) | 127 (48.7) | 125 (47.7) | 0.878 |
  Tolvaptan | 31 (3.0) | 7 (2.6) | 8 (3.1) | 4 (1.5) | 12 (4.6) | 0.225 |
  Sacubitril/valsartan | 368 (35.1) | 85 (32.1) | 97 (37.2) | 86 (33.0) | 100 (38.2) | 0.367 |
 Oral hypoglycemic agents |  |  |  |  |  |  |
  Metformin | 268 (25.6) | 54 (20.4) | 64 (24.5) | 72 (27.6) | 78 (29.8) | 0.075 |
  Alpha‑glucosidase inhibitor | 195 (18.6) | 54 (20.4) | 45 (17.2) | 46 (17.6) | 50 (19.1) | 0.783 |
  Sulfonylurea | 55 (5.2) | 21 (7.9) | 14 (5.4) | 6 (2.3) | 14 (5.3) | 0.038 |
  SGLT2 inhibitor | 402 (38.3) | 98 (37.0) | 104 (39.9) | 101 (38.7) | 99 (37.8) | 0.142 |
  DDP4 depressor | 70 (6.7) | 11 (4.2) | 16 (6.1) | 15 (5.8) | 28 (10.7) | 0.019 |
 Insulin | 402 (38.3) | 101 (38.1) | 96 (36.8) | 96 (36.8) | 109 (41.6) | 0.632 |
 Oral anticoagulants |  |  |  |  |  |  |
  Warfarin | 20 (1.9) | 4 (1.5) | 5 (1.9) | 6 (2.3) | 5 (1.9) | 0.932 |
  Factor Xa inhibitors | 17 (1.6) | 6 (2.3) | 5 (1.9) | 3 (1.2) | 3 (1.2) | 0.667 |
  Factor IIa inhibitors | 10 (1.0) | 3 (1.1) | 4 (1.5) | 2 (0.8) | 1 (0.4) | 0.568 |