| Model 1 | Model 2 | Model 3 | ||||||
---|---|---|---|---|---|---|---|---|---|
HR (95% CIs) | P | P for trend | HR (95% CIs) | P | P for trend | HR (95% CIs) | P | P for trend | |
MACE |  |  |  < 0.001 |  |  |  < 0.001 |  |  |  < 0.001 |
 Quartile 1: MHR < 0.33 | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  |
 Quartile 2: 0.33 ≤ MHR < 0.46 | 1.66 (1.20–2.29) | 0.002 |  | 1.66 (1.20–2.30) | 0.002 |  | 1.59 (1.15–2.22) | 0.006 |  |
 Quartile 3: 0.46 ≤ MHR < 0.62 | 2.00 (1.47–2.74) |  < 0.001 |  | 2.04 (1.48–2.80) |  < 0.001 |  | 1.89 (1.37–2.62) |  < 0.001 |  |
 Quartile 4: MHR ≥ 0.62 | 2.82 (2.09–3.80) |  < 0.001 |  | 2.83 (2.09–3.29) |  < 0.001 |  | 2.29 (1.66–3.18) |  < 0.001 |  |
 Continuous | 3.03 (2.20–4.18) |  < 0.001 |  | 1.74 (2.08–3.85) |  < 0.001 |  | 2.11 (1.47–3.03) |  < 0.001 |  |
All-cause mortality |  |  |  < 0.001 |  |  |  < 0.001 |  |  | 0.003 |
 Quartile 1: MHR < 0.33 | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  |
 Quartile 2: 0.33 ≤ MHR < 0.46 | 1.66 (1.06–2.61) | 0.028 |  | 1.69 (1.07–2.67) | 0.026 |  | 1.66 (1.04–2.66) | 0.035 |  |
 Quartile 3: 0.46 ≤ MHR < 0.62 | 2.02 (1.30–3.14) | 0.002 |  | 2.07 (1.32–3.26) | 0.002 |  | 1.98 (1.25–3.13) | 0.003 |  |
 Quartile 4: MHR ≥ 0.62 | 2.50 (1.63–3.85) |  < 0.001 |  | 2.56 (1.65–3.99) |  < 0.001 |  | 2.05 (1.28–3.29) | 0.003 |  |
 Continuous | 2.85 (1.78–4.56) |  < 0.001 |  | 2.80 (1.74–4.50) |  < 0.001 |  | 1.94 (1.14–3.29) | 0.015 |  |
Nonfatal MI | Â | Â | 0.002 | Â | Â | 0.004 | Â | Â | 0.006 |
 Quartile 1: MHR < 0.33 | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  |
 Quartile 2: 0.33 ≤ MHR < 0.46 | 1.97 (0.66–5.89) | 0.223 |  | 1.91 (0.63–5.76) | 0.253 |  | 1.79 (0.58–5.48) | 0.308 |  |
 Quartile 3: 0.46 ≤ MHR < 0.62 | 2.76 (0.97–7.85) | 0.056 |  | 2.68 (0.93–7.75) | 0.068 |  | 2.53 (0.86–7.42) | 0.091 |  |
 Quartile 4: MHR ≥ 0.62 | 4.16 (1.53–11.29) | 0.005 |  | 3.99 (1.44–11.09) | 0.008 |  | 3.90 (1.35–11.28) | 0.012 |  |
 Continuous | 4.56 (1.85–11.23) | 0.001 |  | 1.54 (1.15–2.05) | 0.004 |  | 4.53 (1.66–12.39) | 0.003 |  |
Any revascularization |  |  |  < 0.001 |  |  |  < 0.001 |  |  | 0.001 |
 Quartile 1: MHR < 0.33 | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  | 1.0 (Ref) |  |  |
 Quartile 2: 0.33 ≤ MHR < 0.46 | 1.60 (0.97–2.63) | 0.066 |  | 1.58 (0.95–2.62) | 0.077 |  | 1.52 (0.91–2.54) | 0.108 |  |
 Quartile 3: 0.46 ≤ MHR < 0.62 | 1.85 (1.14–3.03) | 0.013 |  | 1.87 (1.13–3.07) | 0.014 |  | 1.70 (1.02–2.81) | 0.040 |  |
 Quartile 4: MHR ≥ 0.62 | 2.94 (1.86–4.65) |  < 0.001 |  | 2.91 (1.82–4.65) |  < 0.001 |  | 2.31 (1.40–3.81) | 0.001 |  |
 Continuous | 2.90 (1.75–4.79) |  < 0.001 |  | 2.72 (1.64–4.51) |  < 0.001 |  | 1.93 (1.10–3.39) | 0.023 |  |