Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Table 1 Analysis of all dengue patients with different DENV serotypes

Demographic Characteristics^a	DENV-1	DENV-2	P value	Logistic regression
Demographic Characteristics^a	n = 105	n = 1550	P value	P value	OR (95% CI)
Age (Years)	48 (3–88)	52 (0–91)	0.079	0.235	1.007
0–59	78 (74.3%)	975 (62.9%)	0.019	0.27	1.524 (0.721–3.223)
≥60	27 (25.7%)	575 (37.1%)	0.019	0.27	1.524 (0.721–3.223)
0–9	4 (3.8%)	50 (3.2%)	0.011	0.104
10–19	5 (4.8%)	121 (7.8%)			1.934 (0.499–7.503)
20–29	23 (21.9%)	170 (11.0%)			0.588 (0.194–1.780)
30–39	12 (11.4%)	242 (15.6%)			1.603 (0.496–5.179)
40–49	12 (11.4%)	145 (9.4%)			1.018 (0.312–3.317)
50–59	22 (21.0%)	247 (15.9%)			0.851 (0.265–2.735)
60–69	14 (13.3%)	273 (17.6%)			1.329 (0.353–5.002)
≥70	13 (12.4%)	302 (19.5%)			1.507 (0.294–7.741)
Sex
Male	56 (53.3%)	792 (51.1%)	0.657
Female	49 (46.7%)	758 (48.9%)	0.657
Days PSO	2 (0–8)	2 (0–22)	0.879
Disease severity
Dengue fever	103 (98.1%)	1443 (93.1%)	0.046	0.223	3.486 (0.469–25.935)
Severe dengue	2 (1.9%)	107 (6.9%)	0.046	0.223	3.486 (0.469–25.935)
Chronic disease^b
Diabetes mellitus	6 (5.9%)	163 (11.1%)	0.101
Hypertension	15 (14.7%)	248 (16.8%)	0.575
Congestive heart failure	3 (2.9%)	29 (2.0%)	0.502
COPD	6 (5.9%)	66 (4.5%)	0.513
Cerebrovascular disease	3 (2.9%)	65 (4.4%)	0.479
Moderate to severe CKD^c	2 (2.0%)	21 (1.4%)	0.664
Charlson comorbidity index score^b	1 (0–7)	1 (0–10)	0.031	0.426	1.088 (0.884–1.339)
Outcome^d
Survived	103 (98.1%)	1498 (96.9%)	0.487
Death	2 (1.9%)	48 (3.1%)	0.487

^aPresented as the numbers (%) except for average age, days PSO, and CCI score, which are shown as the median (range)
^bN = 1,574, DENV-1 = 102, DENV-2 = 1,472. COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease
^cModerate CKD: stage 3A & 3B (GFR 45–59 ml/min & 30–44 ml/min), Severe CKD: stage 4 & 5 (GFR 15–29 ml/min & less than 15 ml/min)
^dThere were four patients who did not die from dengue fever in the DENV-2 group and were excluded from the analysis

ISSN: 2047-783X