Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Table 2 Analysis of all dengue patients with different severities

Demographic Characteristics^a	Dengue fever	Severe dengue	P value	Logistic regression
Demographic Characteristics^a	n = 1546	n = 109	P value	P value	OR (95% CI)
Age (Years)	50 (0–91)	72 (16–91)	< 0.001	0.206	3.687 (0.488–27.845)
0–59	1025 (66.3%)	28 (25.7%)	< 0.001	0.12	1.931 (0.842–4.429)
≥60	521 (33.7%)	81 (74.3%)	< 0.001	0.12	1.931 (0.842–4.429)
0–9	54 (3.5%)	0	< 0.001
10–19	125 (8.1%)	1 (0.9%)
20–29	193 (12.5%)	0
30–39	246 (15.9%)	8 (7.3%)
40–49	152 (9.8%)	5 (4.6%)
50–59	255 (16.5%)	14 (12.9%)
60–69	269 (17.4%)	18 (16.5%)
≥ 70	252 (16.3%)	63 (57.8%)
Sex
Male	793 (51.3%)	55 (50.5%)	0.866
Female	753 (48.7%)	54 (49.5%)	0.866
Days PSO	2 (0–22)	2 (0–7)	0.755
Serotype
DENV-1	103 (6.7%)	2 (1.8%)	0.046	0.196	3.818 (0.501–29.118)
DENV-2	1443 (93.3%)	107 (98.2%)	0.046	0.196	3.818 (0.501–29.118)
Chronic disease^b
Diabetes mellitus	143 (9.5%)	26 (39.4%)	< 0.001	0.028	2.178 (1.088–4.362)
Hypertension	234 (15.5%)	29 (43.9%)	< 0.001	0.607	1.178 (0.631–2.201)
Congestive heart failure	28 (1.9%)	4 (6.1%)	0.018	0.953	1.038 (0.308–3.499)
COPD	63 (4.2%)	9 (13.6%)	< 0.001	0.785	1.129 (0.473–2.695)
Cerebrovascular disease	63 (4.2%)	5 (7.6%)	0.184
Moderate to severe CKD	15 (1.0%)	8 (12.1%)	< 0.001	0.001	5.806 (1.994–16.902)
Charlson comorbidity index score^b	1 (0–10)	4 (0–8)	< 0.001	0.05	1.239 (1.000–1.534)
Outcome^c
Survived	1533 (99.3%)	68 (63.6%)	< 0.001
Death	11 (0.7%)	39 (36.4%)	< 0.001

^aPresented as the numbers (%) except for average age, days PSO, and CCI score, which are shown as the median (range)
^bN = 1,574, Dengue fever = 1,508, Severe dengue = 66. COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease
^cThere are two patients who did not die from either dengue fever or severe dengue

ISSN: 2047-783X