Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Table 3 Analysis of mortality in all dengue patients

Demographic Characteristics^a	Survived	Death	P value	Logistic regression
Demographic Characteristics^a	n = 1601	n = 50	P value	P value	OR (95% CI)
Age (Years)	50 (0–91)	74 (48–88)	< 0.001	0.167	1.044 (0.982–1.109)
0–59	1046 (65.3%)	7 (14.0%)	< 0.001	0.617	0.658 (0.128–3.392)
≥60	555 (34.7%)	43 (86.0%)	< 0.001	0.617	0.658 (0.128–3.392)
0–9	54 (3.4%)	0	< 0.001
10–19	126 (7.9%)	0
20–29	193 (12.0%)	0
30–39	254 (15.9%)	0
40–49	156 (9.7%)	1 (2.0%)
50–59	263 (16.4%)	6 (12.0%)
60–69	281 (17.6%)	5 (10.0%)
≥70	274 (17.1%)	38 (76.0%)
Sex
Male	827 (51.7%)	18 (36.0%)	0.029	0.065	2.560 (0.942–6.956)
Female	774 (48.3%)	32 (64.0%)	0.029	0.065	2.560 (0.942–6.956)
Days PSO	2 (0–22)	2 (0–5)	0.717
Serotype
DENV-1	103 (6.4%)	2 (4.0%)	0.487
DENV-2	1498 (93.6%)	48 (96.0%)	0.487
Disease severity
Dengue fever	1533 (95.8%)	11 (22.0%)	< 0.001	< 0.001	115.713 (39.545–338.588)
Severe dengue	68 (4.2%)	39 (78.0%)	< 0.001	< 0.001	115.713 (39.545–338.588)
Chronic disease^b
Diabetes mellitus	151 (9.8%)	14 (45.2%)	< 0.001	0.961	1.032 (0.297–3.583)
Hypertension	247 (16.0%)	15 (48.4%)	< 0.001	0.431	0.639 (0.210–1.948)
Congestive heart failure	28 (1.8%)	4 (12.9%)	< 0.001	0.288	2.707 (0.431–17.015)
COPD	65 (4.2%)	6 (19.4%)	< 0.001	0.681	1.338 (0.334–5.352)
Cerebrovascular disease	64 (4.2%)	3 (9.7%)	0.132
Moderate to severe CKD	20 (1.3%)	3 (9.7%)	< 0.001	0.453	0.517 (0.092–2.898)
Charlson comorbidity index score^b	1 (0–10)	5 (1–8)	< 0.001	0.008	1.686 (1.144–2.484)

^aPresented as the numbers (%) except for average age, days PSO, and CCI score, which are shown as the median (range)
^bN = 1,570, survived = 1,539, death = 31. COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease

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