Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Table 4 Subanalysis of the different severities in DENV-2-infected patients

Demographic Characteristics^a	Dengue fever	Severe dengue	P value	Logistic regression
Demographic Characteristics^a	n = 1407	n = 105	P value	P value	OR (95% CI)
Age (Years)	50 (0–91)	72 (16–91)	< 0.001	0.002	1.049 (1.018–1.082)
0–59	921 (65.5%)	26 (24.8%)	< 0.001	0.067	2.225 (0.947–5.228)
≥60	486 (34.5%)	79 (75.2%)	< 0.001	0.067	2.225 (0.947–5.228)
Sex
Male	719 (51.1%)	53 (50.5%)	0.902
Female	688 (48.9%)	52 (49.5%)	0.902
Chronic disease^b
Diabetes mellitus	136 (9.9%)	26 (40.6%)	< 0.001	0.004	2.818 (1.382–5.748)
Hypertension	216 (15.7%)	29 (45.3%)	< 0.001	0.735	1.114 (0.597–2.079)
Congestive heart failure	25 (1.8%)	4 (6.3%)	0.014	0.739	1.228 (0.367–4.114)
COPD	56 (4.1%)	9 (14.1%)	< 0.001	0.505	1.353 (0.556–3.291)
Cerebrovascular disease	59 (4.3%)	5 (7.8%)	0.183
Moderate to severe CKD	13 (0.9%)	8 (12.5%)	< 0.001	< 0.001	8.065 (2.676–24.308)
Charlson comorbidity index score^b	1 (0–10)	4.5 (0–8)	< 0.001	0.956	0.992 (0.760–1.297)
Outcome^c			< 0.001
Survived	1395 (99.3%)	65 (63.1%)
Death	10 (0.7%)	38 (36.9%)

^aPresented as the numbers (%) except for average age and CCI score, which are shown as the median (range). The days PSO of these patients were ≤ 6 days
^bN = 1,436, Dengue fever = 1,372, Severe dengue = 64. COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease
^cThere are two patients who did not die from dengue fever or severe dengue

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