Correlation analysis of clinical, pathological, imaging and genetic features of ground-glass nodule featured lung adenocarcinomas between high-risk and non-high-risk individuals

Table 1 Baseline data of risk groups

	High risk (509)	Non-high risk (1291)	P value
Gender			< 0.001*
Male	288 (56.58)	257 (19.91)
Female	221 (43.42)	1034 (80.09)
Age			< 0.001*
Mean ± SD	57.58 ± 9.262	53.67 ± 11.590
Smoking history
Yes	265 (52.06)	20 (1.55)	< 0.001*
No	244 (47.94)	1271 (98.45)
Medical history
Tumor	78 (15.32)	6 (0.46)	< 0.001*
Pulmonary fibrosis	1 (0.20)	0	0.283
COPD	4 (0.79)	0	0.006*
Pulmonary tuberculosis	11 (2.16)	2 (0.15)	< 0.001*
Family history of tumors
Lung cancer	192 (37.72)	16 (1.24)	< 0.001*
Other tumors	80 (15.72)	122 (9.45)	< 0.001*
Exposure history
Oil, smoke and dust	9 (1.77)	1 (0.08)	< 0.001*
Asbestos, beryllium, uranium, radon, etc	1 (0.20)	1 (0.08)	0.486
GGN detection way			0.413
Physical examination	302 (59.33)	793 (61.43)
Others	207 (40.67)	498 (38.57)
Clinical stage			0.488
IA	457 (89.78)	1143 (88.54)
IB	48 (9.43)	140 (10.84)
IIB	3 (0.59)	5 (0.39)
IIIA	0	2 (0.15)
IIIB	1 (0.20)	0
IV	0	1 (0.08)
Pathological subtype^c (total = 1237)			< 0.001*
AAH + AIS	29 (8.43)	128 (14.33)
MIA	123 (35.76)	381 (42.67)
IAC	192 (55.81)	384 (43.00)
Time from detection to diagnosis			0.015*
≤ 3 months	242 (47.54)	629 (48.72)
4–12 months	151 (29.67)	440 (34.08)
> 12 months	116 (22.79)	222 (17.2)

^*P < 0.05 or P < 0.01 after Bonferroni correction is considered statistically different
^c1237/1800 cases were classified pathologically according to the existing pathological subtypes

ISSN: 2047-783X